Tuberc Respir Dis.  2016 Jul;79(3):153-157. 10.4046/trd.2016.79.3.153.

Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

• Yuvaraj B
• Sridhar MG
• Kumar SV
• Kadhiravan T

• KMID: 2326683
• DOI: http://doi.org/10.4046/trd.2016.79.3.153

Abstract

BACKGROUND
Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity.
METHODS
Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls.
RESULTS
The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity.
CONCLUSION
Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.

Keyword

Vitamin D; Tuberculosis, Pulmonary

MeSH Terms

Bacterial Load*
Humans
Sputum
Tuberculosis
Tuberculosis, Pulmonary*
Vitamin D*
Vitamins*
Vitamin D
Vitamins

Figure

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  Figure 1 Correlation of serum vitamin D levels with sputum acid fast bacilli (AFB) positivity.

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