Pediatr Gastroenterol Hepatol Nutr.  2019 Sep;22(5):460-469. 10.5223/pghn.2019.22.5.460.

Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents

• Yılmaz R
• AteÅŸ O
• Gül A
• Kasap T
• Özer S
• Ensari E

• KMID: 2457748
• DOI: http://doi.org/10.5223/pghn.2019.22.5.460

Abstract

PURPOSE
The β3-adrenergic receptor (ADRB3) is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study, we aimed to investigate the association of polymorphism of the ADRB3 gene with the sex of children with obesity and related pathologies.
METHODS
ADRB3 gene trp64arg genotyping was conducted in 441 children aged 6-18 years. Among these subjects, 264 were obese (103 boys; 161 girls) and 179 were of normal weight (81 boys; 98 girls). In the obese group, fasting lipids, glucose and insulin levels, and blood pressure were measured. Metabolic syndrome (MS) was defined according to the modified World Health Organization criteria adapted for children.
RESULTS
The frequency of trp64arg genotype was similar in obese and normal weight children. In obese children, serum lipid, glucose, and insulin levels; homeostasis model assessment of insulin resistance (HOMA-IR) scores; and MS were not different between arg allele carriers (trp64arg) and noncarriers (trp64trp). In 264 obese children, genetic analysis results revealed that the arg allele carriers were significantly higher in girls than in boys (p=0.001). In the normal weight group, no statistically significant difference was found between genotypes of boys and girls (p=0.771).
CONCLUSION
Trp64arg polymorphism of the ADRB3 gene was not associated with obesity and MS in Turkish children and adolescents. Although no relationships were observed between the genotypes and lipids, glucose/insulin levels, or HOMA-IR, the presence of trp64arg variant was frequent in obese girls, which can lead to weight gain as well as difficulty in losing weight in women.

Keyword

Obesity; Child; β3-adrenergic receptor; Gene polymorphism

MeSH Terms

Adolescent*
Alleles
Blood Pressure
Child*
Energy Metabolism
Fasting
Female*
Genotype
Glucose
Homeostasis
Humans
Insulin
Insulin Resistance
Intra-Abdominal Fat
Lipolysis
Obesity
Pathology
Weight Gain
World Health Organization
Glucose
Insulin

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