Ann Dermatol.  2014 Feb;26(1):88-91. 10.5021/ad.2014.26.1.88.

Lack of Association between PTPN22 Gene +1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population

• Akbas H
• Dertlioglu SB
• Dilmec F
• Atay AE

• KMID: 2265702
• DOI: http://doi.org/10.5021/ad.2014.26.1.88

Abstract

BACKGROUND
Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders.
OBJECTIVE
The aim of this study was to investigate whether the PTPN22 gene +1858 C>T single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population.
METHODS
One hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism.
RESULTS
The PTPN22 +1858 C>T genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls.
CONCLUSION
We found no association between the PTPN22 +1858 C>T gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.

Keyword

Polymerase chain reaction-restriction fragment length polymorphism; PTPN22 gene; Vitiligo

MeSH Terms

Gene Frequency
Genotype
Humans
Melanocytes
Pigmentation
Polymorphism, Single Nucleotide
Vitiligo*