Korean J Intern Med.  2019 Sep;34(5):1145-1153. 10.3904/kjim.2017.304.

Treatment patterns of knee osteoarthritis patients in Korea

Affiliations
  • 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea. sungyk@hanyang.ac.kr
  • 2Department of Statistics, Kyungpook National University, Daegu, Korea.
  • 3Chung-Ang University Collage of Pharmacy, Seoul, Korea.
  • 4Department of Information Statistics, Andong National University, Andong, Korea.

Abstract

BACKGROUND/AIMS
To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea.
METHODS
Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed. Prevalence and characteristics of knee OA patients who received a CS intra-articular injection (IAI) were also evaluated.
RESULTS
We identified 2,016,516 knee OA patients whose age (mean ± standard deviation) was 63.2 ± 10.8 years. The number of patients with at least one use of NSAIDs, analgesics, CS, and SYSADOA were 82.5%, 32.2%, 8.6%, and 43.4%, respectively. The use of herbal SYSADOAs was 29.7%. For regular users (medication possession ratios ≥ 50%), the use of NSAIDs was substantially decreased (48.8%), while the use of SYSADOA (37.3%) and CS (6.7%) were not significantly changed. The number of CS IAI users among knee OA patients was 0.18%; they were slightly older (64.4 ± 10.9 vs. 63.2 ± 10.8, p < 0.01) and more skewed towards females (75.7% vs. 71.5%, p < 0.01) than patients who had not received CS IAI.
CONCLUSIONS
In Korea, the use of SYSADOA or CS in knee OA patients was relatively high. Further studies on the effectiveness and the safety of these treatment options for knee OA are needed.

Keyword

Knee; Osteoarthritis; Therapeutics

MeSH Terms

Adrenal Cortex Hormones
Analgesics
Anti-Inflammatory Agents, Non-Steroidal
Female
Humans
Injections, Intra-Articular
Knee*
Korea*
Osteoarthritis
Osteoarthritis, Knee*
Prevalence
Adrenal Cortex Hormones
Analgesics
Anti-Inflammatory Agents, Non-Steroidal
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