J Dent Anesth Pain Med.  2019 Aug;19(4):209-215. 10.17245/jdapm.2019.19.4.209.

An in vivo study comparing efficacy of 0.25% and 0.5% bupivacaine in infraorbital nerve block for postoperative analgesia

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India. sonalbshah@rediffmail.com

Abstract

BACKGROUND
Pain is an unpleasant sensation ranging from mild localized discomfort to agony and is one of the most commonly experienced symptoms in oral surgery. Usually, local anesthetic agents and analgesics are used for pain control in oral surgical procedures. Local anesthetic agents including lignocaine and bupivacaine are routinely used in varying concentrations. The present study was designed to evaluate and compare the efficacy of 0.25% and 0.5% bupivacaine for postoperative analgesia in infraorbital nerve block.
METHODS
Forty-one patients undergoing bilateral maxillary orthodontic extraction received 0.5% bupivacaine (n = 41) on one side and 0.25% bupivacaine (n = 41) on the other side at an interval of 7 d. The parameters evaluated for both the bupivacaine concentrations were onset of action, pain during procedure (visual analog scale score [VAS]), and duration of action. The results were noted, tabulated, and analyzed using the Wilcoxon signed rank test.
RESULTS
The onset of action of 0.5% bupivacaine was quicker than that of 0.25% bupivacaine, but the difference was not statistically significant (P = 0.306). No significant difference was found between the solutions for VAS scores (P = 0.221) scores and duration of action (P = 0.662).
CONCLUSION
There was no significant difference between 0.25% bupivacaine and 0.5% bupivacaine in terms of onset of action, pain during procedure, and duration of action. The use of 0.25% bupivacaine is recommended.

Keyword

Bupivacaine; Local Anesthesia; Postoperative Pain; Tooth Extraction

MeSH Terms

Analgesia*
Analgesics
Anesthesia, Local
Anesthetics
Bupivacaine*
Humans
Lidocaine
Nerve Block*
Oral Surgical Procedures
Pain, Postoperative
Sensation
Surgery, Oral
Tooth Extraction
Analgesics
Anesthetics
Bupivacaine
Lidocaine
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