Korean J Dermatol.  2019 Jul;57(6):332-334.

Acquired Reactive Perforating Collagenosis as a Preceding Manifestation of Hodgkin's Lymphoma

• Lee SY
• Bang CH
• Park YM
• Lee JY
• Lee JH

Abstract

A 40-year-old man presented with pruritic, multiple, variable-sized, erythematous umbilicated papules on the trunk and both extremities for 4 months. He was diagnosed with Hodgkin's lymphoma (stage IIA) after histopathologic examination of a neck mass that developed a month ago. A punch biopsy was performed on his right lower leg. Histological examination showed transepidermal elimination of the degenerated collagen. Masson's trichrome staining was performed to distinguish collagen fibers from the muscular tissue; using Masson's stain, the collagen appeared as a bluish color crossing from the dermis to the epidermis. The diagnosis of acquired reactive perforating collagenosis was made. The skin lesions showed much improvement after 6 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Acquired perforating disorders are a group of cutaneous disorders that occur in adults with chronic kidney disease or diabetes mellitus. Cases of acquired perforating disorders associated with Hodgkin's lymphoma have been rarely reported in the English literature. To our knowledge, this is the first case of acquired reactive perforating collagenosis in a Korean patient with Hodgkin's lymphoma.

Keyword

Acquired perforating disorder; Acquired reactive perforating collagenosis; Hodgkin's lymphoma

MeSH Terms

Adult
Biopsy
Bleomycin
Collagen
Dacarbazine
Dermis
Diabetes Mellitus
Diagnosis
Doxorubicin
Drug Therapy
Epidermis
Extremities
Hodgkin Disease*
Humans
Leg
Neck
Renal Insufficiency, Chronic
Skin
Vinblastine
Bleomycin
Collagen
Dacarbazine
Doxorubicin
Vinblastine