Korean J Dermatol.  2007 Nov;45(11):1230-1232.

Treatment of Recalcitrant Acquired Reactive Perforating Collagenosis with Low-dose Allopurinol

• Shin MS
• Lee DR
• Park MY

Abstract

Reactive perforating collagenosis is one of a range of essential perforating disorders and is characterized by the transepithelial elimination of altered collagen. Two types have been recognized: the inherited, or childhood form and the acquired, or adult form. Acquired reactive perforating collagenosis is associated with systemic diseases, especially diabetes mellitus and/or renal failure. We report that a low-dose allopurinol showed dramatic effects on acquired reactive perforating collagenosis, which was associated with hypothyroidism and chronic renal failure caused by diabetic nephropathy.

Keyword

Acquired reactive perforating collagenosis; Allopurinol

MeSH Terms

Adult
Allopurinol*
Collagen
Diabetes Mellitus
Diabetic Nephropathies
Humans
Hypothyroidism
Kidney Failure, Chronic
Renal Insufficiency
Allopurinol
Collagen