Int J Oral Biol.  2019 Jun;44(2):37-42. 10.11620/IJOB.2019.44.2.37.

Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma

• Son SH
• Chung WY

• KMID: 2452745
• DOI: http://doi.org/10.11620/IJOB.2019.44.2.37

Abstract

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.

Keyword

Oral squamous cell carcinoma; Bone invasion; Growth factors; Cytokines; Proteases

MeSH Terms

Bone Resorption
Carcinoma, Squamous Cell*
Cytokines*
Epithelial Cells*
Intercellular Signaling Peptides and Proteins*
Jaw
Patient Selection
Peptide Hydrolases*
Public Health
Quality of Life
Cytokines
Intercellular Signaling Peptides and Proteins
Peptide Hydrolases