Ewha Med J.  1996 Sep;19(3):349-357. 10.12771/emj.1996.19.3.349.

Expression of Tumor Necrosis Factor-Alpha and Interleukin-6 in Larynx Squamous Cell Carcinoma

• Chung SM
• Kim SS

• KMID: 2170903
• DOI: http://doi.org/10.12771/emj.1996.19.3.349

Abstract

BACKGROUND
The host immune system normally functions to destroy neoplastic cells that continually develop as a result of somatic mutations. However, patients with head and neck squamous cell carcinoma have depressed cell-mediated immune function, which has recently been shown to be most pronounced in the local and regional environment of the primary tumor. Recent studies suggest a local modulation of the host immune response to tumor by secreted immunoregulatory factors such as cytokines, especially pro-inflammatory cytokines(interleukin-1, interleukin-6, interleukin-8, interferons, and tumor necrosis factor).
MATERIALS AND METHODS
To assessthe ability of head and neck squamous cell carcinoma to produce these cytokines, initially, we have performed immunohistochemical staing for interleukin-6 and tumor necrosis factor in 20 cases of laryngeal squamous cell carcinoma and 10 cases of laryngeal nodule as a control group.
RESULTS
We detected interleukin-6 in 11 cases of laryngeal squamous cell carcinoma(55%) and tumor necrosis factor in 11 cases of laryngeal squamous cell carcinoma(55%). All of 10 papillomas showed no expression of interleukin-6 and tumor necrosis factor. There is no statistical correlation between interleukin-6 and tumor necrosis factor expression and clinical stage or pathologic grade.
CONCLUSION
These results suggest that laryngeal squamous cell carcinoma may secrete cytokines influencing the response of local immune cells. But future studies of the role of tumorderived cytokines in the local immune response to tumor could be investigated,since cytokines may directly or indirectly regulate tumor growth and metastasis.

Keyword

TNF-alpha; Interleukin-6; Laryngeal squamous cell carcinoma

MeSH Terms

Carcinoma, Squamous Cell*
Cytokines
Head
Humans
Immune System
Interferons
Interleukin-6*
Interleukin-8
Larynx*
Neck
Necrosis
Neoplasm Metastasis
Papilloma
Tumor Necrosis Factor-alpha*
Cytokines
Interferons
Interleukin-6
Interleukin-8
Tumor Necrosis Factor-alpha