Nucl Med Mol Imaging.
2019 Apr;53(2):115-124. 10.1007/s13139-019-00584-z.
Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies
- Affiliations
-
- 1Department of Nuclear Medicine,Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Biomedical Research Institute, Chonbuk National UniversityMedical School and Hospital, Jeonju, Jeonbuk 54907, Republic of Korea. hkkim717@jbnu.ac.kr
- KMID: 2448099
- DOI: http://doi.org/10.1007/s13139-019-00584-z
Abstract
- Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, â¸â¹Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as â¸â¹Zr chelators, and new coordinating methods have also been developed more recently. In addition, immunopositron emission tomography (PET) studies using â¸â¹Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of â¸â¹Zr and the utilization of â¸â¹Zr in PET studies are described.
