Nucl Med Mol Imaging.  2019 Apr;53(2):115-124. 10.1007/s13139-019-00584-z.

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

Affiliations
  • 1Department of Nuclear Medicine,Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Biomedical Research Institute, Chonbuk National UniversityMedical School and Hospital, Jeonju, Jeonbuk 54907, Republic of Korea. hkkim717@jbnu.ac.kr

Abstract

Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, ⁸⁹Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as ⁸⁹Zr chelators, and new coordinating methods have also been developed more recently. In addition, immunopositron emission tomography (PET) studies using ⁸⁹Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of ⁸⁹Zr and the utilization of ⁸⁹Zr in PET studies are described.

Keyword

⁸⁹Zr; Positron emission tomography (PET); Coordination; Ligand

MeSH Terms

Antibodies, Monoclonal
Chelating Agents
Electrons*
Ligands
Metals
Molecular Imaging
Positron-Emission Tomography*
Antibodies, Monoclonal
Chelating Agents
Ligands
Metals
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