Int J Oral Biol.  2019 Mar;44(1):20-26. 10.11620/IJOB.2019.44.1.20.

Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression

Affiliations
  • 1Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea. mkbae@pusan.ac.kr
  • 2Department of Orthodontics, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
  • 3Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.

Abstract

Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.

Keyword

Porphyromonas gingivalis; Vascular smooth muscle cells; Matrix metalloproteinase 9; STAT3 transcription factor

MeSH Terms

Animals
Atherosclerosis
Cardiovascular Diseases
Cell Movement*
Matrix Metalloproteinase 9*
Muscle, Smooth, Vascular*
Periodontal Diseases
Porphyromonas gingivalis*
Porphyromonas*
Rats
RNA, Messenger
STAT3 Transcription Factor
Transducers*
Matrix Metalloproteinase 9
RNA, Messenger
STAT3 Transcription Factor
Full Text Links
  • IJOB
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr