Gut Liver.  2019 Mar;13(2):154-160. 10.5009/gnl17556.

Insulin Resistance Is Associated with Early Gastric Cancer: A Prospective Multicenter Case Control Study

• Kwon HJ
• Park MI
• Park SJ
• Moon W
• Kim SE
• Kim JH
• Choi YJ
• Lee SK

• KMID: 2446799
• DOI: http://doi.org/10.5009/gnl17556

Abstract

BACKGROUND/AIMS
Recently, increased body weight has been found to be associated with an increasing risk of several cancers, including gastric cancer. The true pathogenic role of hyperglycemia in the development of gastric cancer remains unclear as hyperglycemia and its associated conditions may work as carcinogenic factors. The goal of this study was to clarify the factors associated with early gastric cancer and evaluate a homeostasis model assessment of the insulin resistance (HOMA-IR) index, fasting glucose, and lipid profile as predictors of early gastric cancer.
METHODS
A total of 63 patients with early gastric cancer between November 2012 and March 2013 were included. Preoperative serum lipid profile levels and serum fasting glucose were examined prospectively in patients with early gastric cancer. The same number of controls were evaluated and matched to the early gastric cancer group for age and gender. We performed multivariate logistic regression analysis to identify independent risk factors for early gastric cancer.
RESULTS
Univariate analysis showed that risk for early gastric cancer was associated with diastolic blood pressure (BP), total cholesterol, fasting glucose, and HOMA-IR. In the multivariate-adjusted model, higher total cholesterol, fasting glucose, body mass index, and diastolic BP were strongly associated with an increased risk of early gastric cancer.
CONCLUSIONS
Hyperglycemia, a lower high-density lipoprotein cholesterol level, and a low HOMA-IR level appear to be associated with early gastric cancer risk.

Keyword

Early gastric cancer; Hyperglycemia; HOMA-IR; Adiponectin; Cholesterol

MeSH Terms

Adiponectin
Blood Pressure
Body Mass Index
Body Weight
Case-Control Studies*
Cholesterol
Fasting
Glucose
Homeostasis
Humans
Hyperglycemia
Insulin Resistance*
Insulin*
Lipoproteins
Logistic Models
Prospective Studies*
Risk Factors
Stomach Neoplasms*
Adiponectin
Cholesterol
Glucose
Insulin
Lipoproteins