Dement Neurocogn Disord.  2015 Mar;14(1):31-38. 10.12779/dnd.2015.14.1.31.

Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer's Disease

  • 1Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
  • 2Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea.
  • 3Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 4Department of Neurology, The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital, Seoul, Korea.
  • 5Department of Neurology, Inha University College of Medicine, Inha University Hospital, Incheon, Korea.
  • 6Department of Neurology, Wonkwang University College of Medicine, Wonkwang University Sanbon Medical Center, Gunpo, Korea.
  • 7Department of Neurology, VHS Medical Center, Seoul, Korea.
  • 8Department of Neurology, Seonam University College of Medicine, Myongji Hospital, Goyang, Korea.
  • 9Department of Neurology, Jeju National University College of Medicine, Jeju National University Hospital, Jeju, Korea.
  • 10Department of Neurology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, Korea.
  • 11Department of Neurology, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri, Korea.
  • 12Department of Neurology, Ewha Womans University School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
  • 13Department of Neurology, Hanyang University College of Medicine, Hanyang University Seoul Hospital, Seoul, Korea.
  • 14Department of Neurology, Dong-A University College of Medicine, Dong-A University Medical Center, Busan, Korea.
  • 15Department of Neurology, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea.
  • 16Department of Neurology, Konyang University School of Medicine, Konyang University Hospital, Daejeon, Korea.
  • 17Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Medical Center, Seoul, Korea.


The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patients show more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patients with Alzheimer's disease (AD) and the specific factors affecting adverse events of the skin.
A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009 to September 2010 (NCT01312363).
A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinued treatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergic history and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment.
These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding and improving skin tolerability to the rivastigmine patch.


rivastigmine transdermal patch; Alzheimer's disease; tolerability

MeSH Terms

Alzheimer Disease*
Asian Continental Ancestry Group
Hot Temperature
Observational Study


  • Fig. 1 Flow of participants through the study. AD: Alzheimer's disease.

  • Fig. 2 Summary of adverse events (AEs).

  • Fig. 3 Locations of skin adverse events. A: Limited erythema. B: Extended erythema.


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