J Korean Soc Radiol.  2019 Jan;80(1):164-169. 10.3348/jksr.2019.80.1.164.

Diffusion Tensor Imaging and Quantitative Magnetic Resonance Volumetric Assessment in the Diagnosis of Hemimegalencephaly: A Case Report

• Yoo SJ
• Lee JY
• Lee YJ
• Park DW
• Kim TY
• Kim HJ

• KMID: 2442478
• DOI: http://doi.org/10.3348/jksr.2019.80.1.164

Abstract

A 27-year-old female presented with repeated seizures. As the left frontal lobe volume was enlarged in comparison with the right frontal lobe, hemimegalencephaly was suggested. Abnormal white matter fiber tracts running from the left frontal lobe to the fornix and hippocampus were found on diffusion tensor imaging (DTI). We performed quantitative measurements of brain volume and confirmed hemimegalencephaly. DTI and MRI-based volumetry techniques could be useful to objectively diagnose hemimegalencephaly.

MeSH Terms

Adult
Brain
Diagnosis*
Diffusion Tensor Imaging*
Diffusion*
Female
Frontal Lobe
Hemimegalencephaly*
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Running
Seizures
White Matter

Figure

• 

  Fig. 1. A 27-year-old female with feature of hemimegalencephaly on conventional MRI (A-D), DTI (E), and MR volumetry (F). Axial T1-weighted (A) and T2 fluid-attenuated inversion recovery (B) images show asymmetrically broadened gyri of the left frontal lobe with blurring of gray-white matter differentiation. Axial T1-weighted (C) and coronal T2-weighted (D) images demonstrate asymmetric thickened left fornix, which is iso-signal intensity to white matter and mildly compressing the frontal horn of the left lateral ventricle. Aberrant and asymmetric white matter fiber tracts running from the left frontal lobe to the fornix and hippocampus are observed on DTI (E). For MR volumetry, Destrieux atlas based automatic parcellation of cortical surface is overlaied on T1-weighted image (F). DTI = diffusion tensor imaging

Reference

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