Korean J Pediatr Infect Dis.  2002 May;9(1):79-84. 10.14776/kjpid.2002.9.1.79.

Antibiotic Sensitivity Test of Streptococcus pyogenes Obtained in Patients with Streptococcal Infections, 2000

• Kim YH
• Cha SH
• Ma SH
• Kim KS
• Lee YU

• KMID: 2440130
• DOI: http://doi.org/10.14776/kjpid.2002.9.1.79

Abstract

PURPOSE
About 41% of obtained group A streptococci in the 1998 was reported as erythromycin-resistant streptococci in Seoul, Korea. The most common T serotype was T12, followed by T4 and T28. We'd like to monitor the serological changes and antibiotic sensitivity test of Streptococcus pyogenes obtained from the patients with pharyngotonsillitis and invasive diseases from 1999 through 2001. Also, it could be proposed to choose the proper antibiotic selection in the area where the rate of erythromycin-resistant streptococci is high.
METHODS
From Jan. 1999 to Oct. 2001, 208 isolates of group A streptococci were collected from inpatients and outpatients with pharyngotonsillitis, scarlet fever, and invasive infections in Seoul and Southern part of peninsula. All isolates were serotyped by T-agglutination, minimum inhibitory concentrations(MICs) which were determined by agar dilution methods, according to the guidelines of the National Committee for Clinical Laboratory Standards(NCCLS).
RESULTS
The most common T serotype was T12(29.8%), followed by T1(23.1%), T4(14.9%). T1 was prominent serotype compared with previous year. T serotyping, among 25 isolates obtained from the patients with scarlet fever in Southern part of peninsula mostly, was T12, T1, and T4 in order of frequency. All the isolates tested were susceptible to penicillin, cefprozil, vancomycin, ceftriaxone, and chloramphenicol. However, 23 isolates(14.2%) was resistant to erythromycin and 18 isolates(11.1%) was resistant to clarithromycin. Serotype T12 was found to be the most resistant serotype to erythromycin and/or clarithromycin.
CONCLUSION
High rate of erythromycin-resistant streptococci which surveyed in 1998 were reduced to 14.2% in this study. We should have to further evaluate the reason of decreased resistant strains and consider the resistant strains of streptococci in choosing the antibiotics. There was no serological characteristics according to the types of disease entities. Between the serologic distributions in Seoul and the Southern part of peninsula area are same, we could presume that the serological typing of strains obtained over the country may be not different.

Keyword

Streptococcus pyogenes; Antibiotic sensitivity test; Serotype; Erythromycin

MeSH Terms

Agar
Anti-Bacterial Agents
Ceftriaxone
Chloramphenicol
Clarithromycin
Erythromycin
Humans
Inpatients
Korea
Outpatients
Penicillins
Scarlet Fever
Seoul
Serogroup
Serotyping
Streptococcal Infections*
Streptococcus pyogenes*
Streptococcus*
Vancomycin
Agar
Anti-Bacterial Agents
Ceftriaxone
Chloramphenicol
Clarithromycin
Erythromycin
Penicillins
Vancomycin