Korean J Pediatr Infect Dis.  2004 May;11(1):59-72. 10.14776/kjpid.2004.11.1.59.

Rotavirus P and G Genotypes Circulating in Kyungsangnamdo, Korea, during 2000~2001

• So KJ
• Lee MH
• Ma SH
• Kim BC
• Yang JM

• KMID: 2440071
• DOI: http://doi.org/10.14776/kjpid.2004.11.1.59

Abstract

PURPOSE
Rotaviruses are the major cause of gastroenteritis in infants and young children worldwide. It is important to get the epidemiologic data of rotavirus genotype for the application of rotavirus vaccine. So we tried to investigate the distribution of rotavirus genotypes with RT-PCR.
METHODS
A total of 120 rotavirus latex agglutinin test positive stool samples were collected continually from 120 children from Sep. 2000 to Apr. 2001. Rotavirus P(VP4), G(VP7) genotypes were determined by RT-PCR.
RESULTS
The genotype was identified in 116 stool samples of total 120 samples(96%). The incidence of G genotype was as follow; G1 17(14.2%), G2 74(61.7%), G4 1(0.8%), G9 1(0.8%). There were four cases of multiple genotypes; G1/G2, G1/G4, G1/G9, G8/G 9 and genotype of G3, G8 were not found. Twenty three(19.2%) samples were nontypeable. The incidence of P was as follow; P[4] 77(64.2%), P[6] 22(18.3%), P4/P6 12(10%), P[4]/P[8] 1(0.8%) p[8] 1(0.8%). Seven(5.9%) samples were nontypeable.
CONCLUSION
Various combinations of G and P genotypes were observed. Most rotavirus strains were P[4]G2 62(51.74%), followed by P[6]G2 7(5.8%), and P[6]G1 7(5.8%), P[4/P[6]G1 4(3%), P[4]/P[6]G2 4(3%), P[4]G1 3(2.5%), P[8]G2 1(0.8%), P[4]G4 1(0.8%) in Kyoungsangnamdo, Korea during 2000~2001.

Keyword

Rotavirus; VP4; VP7; Genotype

MeSH Terms

Child
Gastroenteritis
Genotype*
Gyeongsangnam-do*
Humans
Incidence
Infant
Korea*
Latex
Rotavirus*
Latex