Korean J Pediatr Gastroenterol Nutr.  2006 Sep;9(2):147-152.

VP7 Genotypes of Group A Rotavirus Isolated from Infants and Toddlers with Rotavirus Gastroenteritis in Jeju

• Kang KS
• Shin KS
• Cui XJ
• Kim W

Abstract

PURPOSE
Efficacy of the new rotavirus vaccines (Rotarix(R), RotaTeq(R)) recently developed can be affected by the rotavirus genotypes prevalent in communities. We performed this study to identify the recent distribution of rotavirus genotypes prevalent in Jeju.
METHODS
Genotyping of human rotaviruses was performed using 81 samples collected from 154 inpatients and outpatients with rotavirus gastroenteritis at Cheju National University Hospital between July 2005 and June 2006. All six (1, 2, 3, 4, 8, 9) G serotypes were identified by amplification of segments of the gene for VP7 using the reverse transcription-polymerase reaction (RT- PCR).
RESULTS
The results of RT-PCR for 81 samples were all positive. G typing of the VP7 protein showed that G1 was the most dominant circulating genotype (65.5%) followed by G2 (14.8%), G3 (13.6%), G8 (1.2%), G9 (1.2%), G4 (0%), and a combination of G1/G3 (3.7%).
CONCLUSION
This distribution of rotavirus VP7 genotypes in Jeju is different from that in other domestic areas; the most dominant circulating genotype was G1.

Keyword

Genotype; Rotavirus; Jeju

MeSH Terms

Gastroenteritis*
Genotype*
Humans
Infant*
Inpatients
Jeju-do
Outpatients
Rotavirus Vaccines
Rotavirus*
Rotavirus Vaccines