Immune Netw.  2019 Feb;19(1):e5. 10.4110/in.2019.19.e5.

The Role of Autophagy in Eosinophilic Airway Inflammation

• Lee J
• Kim HS

• KMID: 2438913
• DOI: http://doi.org/10.4110/in.2019.19.e5

Abstract

Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory diseases, including infectious diseases, Crohn's disease, cystic fibrosis, and pulmonary hypertension. These studies suggest that modulating autophagy could be a novel therapeutic option for inflammatory diseases. Eosinophils are a major type of inflammatory cell that aggravates airway inflammatory diseases, particularly corticosteroid-resistant inflammation. The eosinophil count is a useful tool for assessing which patients may benefit from inhaled corticosteroid therapy. Recent studies demonstrate that autophagy plays a role in eosinophilic airway inflammatory diseases by promoting airway remodeling and loss of function. Genetic variant in the autophagy gene ATG5 is associated with asthma pathogenesis, and autophagy regulates apoptotic pathways in epithelial cells in individuals with chronic obstructive pulmonary disease. Moreover, autophagy dysfunction leads to severe inflammation, especially eosinophilic inflammation, in chronic rhinosinusitis. However, the mechanism underlying autophagy-mediated regulation of eosinophilic airway inflammation remains unclear. The aim of this review is to provide a general overview of the role of autophagy in eosinophilic airway inflammation. We also suggest that autophagy may be a new therapeutic target for airway inflammation, including that mediated by eosinophils.

Keyword

Autophagy; Airway inflammation; Eosinophil

MeSH Terms

Airway Remodeling
Asthma
Autophagy*
Communicable Diseases
Crohn Disease
Cystic Fibrosis
Eosinophils*
Epithelial Cells
Humans
Hypertension, Pulmonary
Inflammation*
Organelles
Pulmonary Disease, Chronic Obstructive