Korean J Dermatol.  2018 May;56(4):251-258.

Analysis of Adverse Cutaneous Drug Reactions using an Electronic Drug Adverse Reaction Reporting System at a Single Secondary Referral Center: A Retrospective Study

• Woo CH
• Choi M
• Yun HJ
• Park HJ

Abstract

BACKGROUND
Adverse cutaneous drug reactions (ACDRs) are common and are responsible for increased morbidity, mortality, and socioeconomic costs.
OBJECTIVE
The purpose of our study was to investigate the common drugs and clinical patterns related to ACDRs using an electronic drug adverse reaction reporting system at a single secondary referral center.
METHODS
We conducted a retrospective analysis of the ACDR database between January 2014 and April 2016 at the Ilsan Paik Hospital.
RESULTS
The study analyzed 320 patients with ACDRs (male:female ratio=93:227; mean age 50.8±17.8 years). Using a Korean causality evaluation algorithm, the percentage of drugs with a possible relationship with ACDRs was calculated to be 50.6%, while the percentage with a probable relationship was 44.7%. Antibiotics (44.0%), radiocontrast media (15.1%), and non-steroidal anti-inflammatory drugs (NSAIDs) (14.3%) were the most commonly implicated drugs. Antibiotics, including cephalosporins (30.6%) and quinolones (10.2%), were responsible for the majority of the ACDRs. Acetic acid (5.9%) and propionic acid (5.9%) derivatives of NSAIDs were also common causative agents. The most common clinical presentations were maculopapular exanthema (33.4%), pruritus (30.9%), and urticaria (25.7%). Severe ACDRs were significantly associated with older age, eosinophilia, and underlying heart and renal diseases (p<0.05).
CONCLUSION
Antibiotics, radiocontrast media, and NSAIDs were identified as common causes of ACDRs. Older age, eosinophilia, heart disease, and renal disease were associated with severe ACDRs.

Keyword

Adverse drug reaction; Adverse drug reaction reporting systems; Drug-related side effects and adverse reactions

MeSH Terms

Acetic Acid
Adverse Drug Reaction Reporting Systems
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Cephalosporins
Contrast Media
Diethylpropion
Drug-Related Side Effects and Adverse Reactions
Eosinophilia
Exanthema
Heart
Heart Diseases
Humans
Mortality
Pruritus
Quinolones
Retrospective Studies*
Secondary Care Centers*
Urticaria
Acetic Acid
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Cephalosporins
Contrast Media
Diethylpropion
Quinolones