Clin Pediatr Hematol Oncol.
2018 Apr;25(1):43-49. 10.15264/cpho.2018.25.1.43.
Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study
- Lee S
- Youn JH
- Lim JY
- Chueh HW
- Lee JM
- Suh JK
- Kim JY
- Yang EJ
- Park KM
- Lim YT
- Park J
- Choi EM
- Shim YJ
- Kim HS
- Park SK
- Kong SG
- Choi EJ
- Park ES
- Affiliations
-
- 1Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea. espark@gnu.ac.kr
- 2Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea.
- 3Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea.
- 4Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
- 5Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.
- 6Department of Pediatrics, Inje University Busan Paik Hospital, Busan, Korea.
- 7Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.
- 8Department of Pediatrics, Ulsan University College of Medicine, Ulsan, Korea.
- 9Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
- 10Department of Pediatrics, College of Medicine, Daegu Catholic University, Daegu, Korea.
- 11Health Science Institute, Gyeongsang National University College of Medicine, Jinju, Korea.
- KMID: 2435423
- DOI: http://doi.org/10.15264/cpho.2018.25.1.43
Abstract
- BACKGROUND
Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it's incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea.
METHODS
Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed.
RESULTS
The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0-23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anticoagulation treatment. Most (52.0%) were treated for more than 90 days.
CONCLUSION
Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
MeSH Terms
-
Abdomen
Adult
Catheters
Child
Diagnosis
Epidemiology
Health Personnel
Homocysteine
Hospitals, University
Humans
Incidence
Korea*
Lower Extremity
Magnetic Resonance Imaging
Male
Medical Records
Pediatrics
Prognosis
Protein C
Protein S
Retrospective Studies
Risk Factors
Thrombosis
Upper Extremity
Venous Thromboembolism*
Homocysteine
Protein C
Protein S
