Asia Pac Allergy.  2019 Jan;9(1):e2. 10.5415/apallergy.2019.9.e2.

Allergy to carminic acid: in vitro evidence of involvement of protein-binding hapten

Affiliations
  • 1Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. myama@med.teikyo-u.ac.jp
  • 2National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
  • 3National Institute of Health Sciences, Tokyo, Japan.

Abstract

We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as a food additive. In this study, highly pure carminic acid was added to an albumin-containing buffer at various concentrations, followed by serial dilution. Varying the mixing ratio of carminic acid and albumin affected the extent of histamine release from passively sensitized basophils. Similar basophil histamine release occurred with carminic acid-globulin solutions. These results provide experimental evidence indicating that basophil activation is dependent on hapten (carminic acid) and carrier (protein) interaction.

Keyword

Anaphylaxis; Basophils; Cochineal dye; Hapten-carrier; Histamine release

MeSH Terms

Anaphylaxis
Basophils
Carmine*
Food Additives
Histamine Release
Hypersensitivity*
In Vitro Techniques*
Carmine
Food Additives
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