J Korean Acad Prosthodont.  2019 Jan;57(1):8-17. 10.4047/jkap.2019.57.1.8.

Prevalence and risk factors of peri-implantitis: A retrospective study

• Lee SE
• Kim DY
• Lee JB
• Pang EK

• KMID: 2431996
• DOI: http://doi.org/10.4047/jkap.2019.57.1.8

Abstract

PURPOSE
The study analyzed the prevalence of peri-implantitis and factors which may have affected the disease.
MATERIALS AND METHODS
This study based on medical records and radiographs of 422 patients (853 implant cases) who visited Ewha Womans University Mokdong Hospital Dental Center from January 1, 2012 to December 31, 2016. Generalized estimation equations (GEE) was utilized to determine the statistical relationship between peri-implantitis and each element, and the cumulative prevalence of peri-implantitis during the observation period was obtained by using the Kaplan Meier Method.
RESULTS
The prevalence rate of peri-implantitis at the patient level resulted in 7.3% (31 patients out of a total of 422 patients), and at the implant level 5.5% (47 implants out of a total of 853 implants). Sex, GBR, guided bone regeneration (GBR) and functional loading periods had statistical significance with the occurrence of peri-implantitis. Upon analysis of the cumulative prevalence of peri-implantitis in terms of implant follow-up period, the first case of peri-implantitis occurred at 9 months after the placement of an implant, and the prevalence of peri-implantitis showed a non-linear rise over time without a hint of a critical point.
CONCLUSION
The prevalence of peri-implantitis at the patient level and the implant were 7.3% and 5.5%, respectively. Male, implant installed with GBR and longer Functional Loading Periods were related with the risk of peri-implantitis.

Keyword

Peri-implantitis; Prevalence; Retrospective study

MeSH Terms

Bone Regeneration
Female
Follow-Up Studies
Humans
Male
Medical Records
Methods
Peri-Implantitis*
Prevalence*
Retrospective Studies*
Risk Factors*

Figure

• 

  Fig. 1. Risk factors of implant according to follow-up period using Kaplan Meier method.

Reference

1.Albrektsson T., Donos N., Thoma D., Pjetursson B., Eugenio R., Brägger U., Esposito M., Kohal R., Nähri T., Storeilli S., Tomasi C., Watzek G., Zwahlen R., Kapos T., Zwahlen M., Lustenberger F., Holmes N. Implant survival and complications. The Third EAO consensus conference 2012. Clin Oral Implants Res. 2012. 23:63–5.

2.Bränemark PI., Adell R., Breine U., Hansson BO., Lindström J., Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg. 1969. 3:81–100.

3.Brånemark PI. Osseointegration and its experimental background. J Prosthet Dent. 1983. 50:399–410.

4.Saadoun AP., LeGall ML. Clinical results and guidelines on Steri-Oss endosseous implants. Int J Periodontics Restorative Dent. 1992. 12:486–95.

5.Gotfredsen K., Nimb L., Hjörting-Hansen E., Jensen JS., Hol-mén A. Histomorphometric and removal torque analysis for TiO2-blasted titanium implants. An experimental study on dogs. Clin Oral Implants Res. 1992. 3:77–84.

6.Cordioli G., Majzoub Z., Piattelli A., Scarano A. Removal torque and histomorphometric investigation of 4 different titanium surfaces: an experimental study in the rabbit tibia. Int J Oral Maxillofac Implants. 2000. 15:668–74.

7.Berglundh T., Lindhe J., Marinello C., Ericsson I., Liljenberg B. Soft tissue reaction to de novo plaque formation on implants and teeth. An experimental study in the dog. Clin Oral Implants Res. 1992. 3:1–8.

8.Pontoriero R., Tonelli MP., Carnevale G., Mombelli A., Ny-man SR., Lang NP. Experimentally induced peri-implant mucositis. A clinical study in humans. Clin Oral Implants Res. 1994. 5:254–9.

9.Albektsson T., Isidor F. Consensus report of session IV. Lang NP, Karring T, editors. Proceedings of the 1st European Workshop on Periodontology. London: Quintessence Publishing;1994. p. 365–9.

10.Ong CT., Ivanovski S., Needleman IG., Retzepi M., Moles DR., Tonetti MS., Donos N. Systematic review of implant outcomes in treated periodontitis subjects. J Clin Periodontol. 2008. 35:438–62.

11.Heitz-Mayfield LJ. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol. 2008. 35:292–304.

12.Esposito M., Murray-Curtis L., Grusovin MG., Coulthard P., Worthington HV. Interventions for replacing missing teeth: different types of dental implants. Cochrane Database Syst Rev. 2007. CD003815.

13.Lang NP., Berglundh T., Heitz-Mayfield LJ., Pjetursson BE., Salvi GE., Sanz M. Consensus statements and recommended clinical procedures regarding implant survival and complications. Int J Oral Maxillofac Implants. 2004. 19:150–4.

14.Roos-Jansåker AM., Lindahl C., Renvert H., Renvert S. Nine-to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol. 2006. 33:290–5.

15.Zitzmann NU., Berglundh T. Definition and prevalence of peri-implant diseases. J Clin Periodontol. 2008. 35:286–91.

16.Jung RE., Pjetursson BE., Glauser R., Zembic A., Zwahlen M., Lang NP. A systematic review of the 5-year survival and complication rates of implant-supported single crowns. Clin Oral Implants Res. 2008. 19:119–30.

17.Park WK., Lee JK., Chang BS., Um HS. A retrospective study on patients' compliance with supportive periodontal therapy. J Korean Acad Periodontol. 2009. 39:59–70.

18.McDermott NE., Chuang SK., Woo VV., Dodson TB. Complications of dental implants: identification, frequency, and associated risk factors. Int J Oral Maxillofac Implants. 2003. 18:848–55.

19.Pjetursson BE., Tan K., Lang NP., Brägger U., Egger M., Zwahlen M. A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years. Clin Oral Implants Res. 2004. 15:667–76.

20.Berglundh T., Persson L., Klinge B. A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years. J Clin Periodontol. 2002. 29:197–212.

21.Renvert S., Polyzois I., Claffey N. How do implant surface characteristics influence peri-implant disease? J Clin Periodontol. 2011. 38:214–22.

22.Quirynen M., De Soete M., van Steenberghe D. Infectious risks for oral implants: a review of the literature. Clin Oral Implants Res. 2002. 13:1–19.

23.Greenstein G., Cavallaro J. Failed dental implants: diagnosis, removal and survival of reimplantations. J Am Dent Assoc. 2014. 145:835–42.

24.Qian J., Wennerberg A., Albrektsson T. Reasons for marginal bone loss around oral implants. Clin Implant Dent Relat Res. 2012. 14:792–807.

25.Padial-Molina M., Suarez F., Rios HF., Galindo-Moreno P., Wang HL. Guidelines for the diagnosis and treatment of peri-implant diseases. Int J Periodontic Restor Dent. 2014. 34:e102–11.

26.Atieh MA., Alsabeeha NH., Faggion CM Jr., Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol. 2013. 84:1586–98.

27.Ferreira SD., Silva GL., Cortelli JR., Costa JE., Costa FO. Prevalence and risk variables for peri-implant disease in Brazilian subjects. J Clin Periodontol. 2006. 33:929–35.

28.Higuchi KW., Folmer T., Kultje C. Implant survival rates in partially edentulous patients: a 3-year prospective multicenter study. J Oral Maxillofac Surg. 1995. 53:264–8.

29.Rinke S., Ohl S., Ziebolz D., Lange K., Eickholz P. Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study. Clin Oral Implants Res. 2011. 22:826–33.

30.Marcantonio C., Nicoli LG., Marcantonio Junior E., Zandim-Barcelos DL. Prevalence and possible risk factors of peri-implantitis: A concept review. J Contemp Dent Pract. 2015. 16:750–7.

31.Vouros ID., Kalpidis CD., Horvath A., Petrie A., Donos N. Systematic assessment of clinical outcomes in bone-level and tissue-level endosseous dental implants. Int J Oral Maxillofac Implants. 2012. 27:1359–74.

32.Fransson C., Tomasi C., Pikner SS., Gröndahl K., Wennström JL., Leyland AH., Berglundh T. Severity and pattern of peri-implantitis-associated bone loss. J Clin Periodontol. 2010. 37:442–8.

33.van der Weijden GA., van Bemmel KM., Renvert S. Implant therapy in partially edentulous, periodontally compromised patients: a review. J Clin Periodontol. 2005. 32:506–11.

34.Schou S., Holmstrup P., Worthington HV., Esposito M. Outcome of implant therapy in patients with previous tooth loss due to periodontitis. Clin Oral Implants Res. 2006. 17:104–23.

35.Karoussis IK., Kotsovilis S., Fourmousis I. A comprehensive and critical review of dental implant prognosis in periodontally compromised partially edentulous patients. Clin Oral Implants Res. 2007. 18:669–79.

36.Quirynen M., Abarca M., Van Assche N., Nevins M., van Steenberghe D. Impact of supportive periodontal therapy and implant surface roughness on implant outcome in patients with a history of periodontitis. J Clin Periodontol. 2007. 34:805–15.

37.Lindhe J, Meyle J, Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008. 35:282–5.

38.Zitzmann NU., Schärer P., Marinello CP. Long-term results of implants treated with guided bone regeneration: a 5-year prospective study. Int J Oral Maxillofac Implants. 2001. 16:355–66.

39.Schmitt A., Zarb GA. The longitudinal clinical effectiveness of osseointegrated dental implants for single-tooth replacement. Int J Prosthodont. 1993. 6:197–202.

40.Krennmair G., Waldenberger O. Clinical analysis of wide-diameter frialit-2 implants. Int J Oral Maxillofac Implants. 2004. 19:710–5.

41.Peñarrocha-Diago MA., Flichy-Fernández AJ., Alonso-González R., Peñarrocha-Oltra D., Balaguer-Martínez J., Peñarrocha-Diago M. Influence of implant neck design and implant-abutment connection type on peri-implant health. Radiological study. Clin Oral Implants Res. 2013. 24:1192–200.

42.Lee SY., Piao CM., Koak JY., Kim SK., Kim YS., Ku Y., Rhyu IC., Han CH., Heo SJ. A 3-year prospective radiographic evaluation of marginal bone level around different implant systems. J Oral Rehabil. 2010. 37:538–44.

43.Gotfredsen K., Rostrup E., Hjörting-Hansen E., Stoltze K., Budtz-Jörgensen E. Histological and histomorphometrical evaluation of tissue reactions adjacent to endosteal implants in monkeys. Clin Oral Implants Res. 1991. 2:30–7.

44.Hermann JS., Cochran DL., Nummikoski PV., Buser D. Crestal bone changes around titanium implants. A radiographic evaluation of unloaded nonsubmerged and submerged implants in the canine mandible. J Periodontol. 1997. 68:1117–30.

45.Derks J., Schaller D., Håkansson J., Wennström JL., Tomasi C., Berglundh T. Peri-implantitis - onset and pattern of progression. J Clin Periodontol. 2016. 43:383–8.