Kosin Med J.  2018 Dec;33(2):263-270. 10.7180/kmj.2018.33.2.263.

A Case of Long-term Survival in a Patient with Primary Primitive Neuroectodermal Tumor of the Lung

• Kang LH
• Kim HJ
• Jang JH
• Kim JH
• Choi KU
• Jeon D

• KMID: 2430745
• DOI: http://doi.org/10.7180/kmj.2018.33.2.263

Abstract

Primitive neuroectodermal tumor (PNET) arising primarily in the lung is an extremely rare and aggressive malignancy with poor chances of patient survival. We present a case of long-term survival by a 29-year-old woman with PNET diagnosed after a hertological and immunohertochemical examination of a biopsy specimen obtained by performing video-assisted thoracic surgery. The patient underwent a left lower lung lobe lobectomy and 6 cycles of adjuvant chemotherapy. The patient has been free of any symptoms of the recurrence of the disease for 6 years after treatment completion.

Keyword

Neuroectodermal Tumors, Primitive; Sarcoma, Ewing; Lung

MeSH Terms

Adult
Biopsy
Chemotherapy, Adjuvant
Female
Humans
Lung*
Neuroectodermal Tumors, Primitive*
Recurrence
Sarcoma, Ewing
Thoracic Surgery, Video-Assisted

Figure

• 

  Fig. 1 Radiological findings. (A) Chest radiograph showed a mass in the left lung. (B) Chest computed tomographic image showed a 5.5-×4.5-cm enhancing mass in the left lower lobe.

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  Fig. 2 Fiberoptic bronchoscopic image showed an endobronchial mass obstructing the superior segment of the left lower lobe.

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  Fig. 3 Pathological findings. (A) Photomicrograph showed diffuse proliferation of small round cells (hematoxylin-eosin [H&E] stain, ×100). (B) Tumor cells showed round-to-oval nuclei with a rosette-like arrangement (H&E stain, ×400). (C) Immunohertochemical staining showed diffuse strong positivity for CD99 (×400).

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