Kosin Med J.  2018 Dec;33(2):263-270. 10.7180/kmj.2018.33.2.263.

A Case of Long-term Survival in a Patient with Primary Primitive Neuroectodermal Tumor of the Lung

  • 1Department of Internal Medicine Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. sooli10@hanmail.net
  • 2Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.


Primitive neuroectodermal tumor (PNET) arising primarily in the lung is an extremely rare and aggressive malignancy with poor chances of patient survival. We present a case of long-term survival by a 29-year-old woman with PNET diagnosed after a hertological and immunohertochemical examination of a biopsy specimen obtained by performing video-assisted thoracic surgery. The patient underwent a left lower lung lobe lobectomy and 6 cycles of adjuvant chemotherapy. The patient has been free of any symptoms of the recurrence of the disease for 6 years after treatment completion.


Neuroectodermal Tumors, Primitive; Sarcoma, Ewing; Lung

MeSH Terms

Chemotherapy, Adjuvant
Neuroectodermal Tumors, Primitive*
Sarcoma, Ewing
Thoracic Surgery, Video-Assisted


  • Fig. 1 Radiological findings. (A) Chest radiograph showed a mass in the left lung. (B) Chest computed tomographic image showed a 5.5-×4.5-cm enhancing mass in the left lower lobe.

  • Fig. 2 Fiberoptic bronchoscopic image showed an endobronchial mass obstructing the superior segment of the left lower lobe.

  • Fig. 3 Pathological findings. (A) Photomicrograph showed diffuse proliferation of small round cells (hematoxylin-eosin [H&E] stain, ×100). (B) Tumor cells showed round-to-oval nuclei with a rosette-like arrangement (H&E stain, ×400). (C) Immunohertochemical staining showed diffuse strong positivity for CD99 (×400).


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