Gut Liver.  2018 Mar;12(2):165-172. 10.5009/gnl17177.

Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant Therapy for Helicobacter pylori Infection

• Jung JH
• Cho IK
• Lee CH
• Song GG
• Lim JH

• KMID: 2429071
• DOI: http://doi.org/10.5009/gnl17177

Abstract

BACKGROUND/AIMS
The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection.
METHODS
We reviewed the medical records of 361 patients who received either STP (n=286) or CT (n=75). The STP group received STT combined with a probiotic preparation for 1 week. The CT group received STT and metronidazole for 1 week.
RESULTS
The intention-to-treat and per-protocol eradication rates were 83.6% (95% confidence interval [CI], 79.0 to 87.7) and 87.1% (95% CI, 81.2 to 89.7) in the STP group and 86.7% (95% CI, 78.7 to 93.3) and 91.4% (95% CI, 83.6 to 97.1) in the CT group (p=0.512 and p=0.324), respectively. The frequency of adverse effects was higher in the CT group (28.2%) than in the STP group (12.8%) (p=0.002).
CONCLUSIONS
STP and CT are encouragingly efficacious as first-line treatments for H. pylori infection. Therefore, adding probiotics to STT may be a feasible option to avoid side effects.

Keyword

Helicobacter pylori; Probiotics; Metronidazole

MeSH Terms

Helicobacter pylori*
Helicobacter*
Humans
Medical Records
Metronidazole
Probiotics*
Research Personnel
Metronidazole