Korean J Helicobacter Up Gastrointest Res.
2011 Sep;11(2):103-111. 10.7704/kjhugr.2011.11.2.103.
Sequential Therapy of Helicobacter pylori Infection
- Affiliations
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- 1Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea. gastro@catholic.ac.kr
- KMID: 2249543
- DOI: http://doi.org/10.7704/kjhugr.2011.11.2.103
Abstract
- The standard therapy for Helicobacter pylori infection in Korea consists of a triple-drug regimen containing a proton pump inhibitor with two antibiotics such as clarithromycin, amoxicillin, and metronidazole. However, the eradication rate of this regimen is declining and a new regimen should be prompted. Among them, sequential therapy seems to be more effective than the conventional triple therapy. Sequential therapy, however, has only been tried in the limited countries such as Italy. To recommend this therapy in clinical practice, well-designed clinical trials should be performed in Korea since many host factors and bacterial factors influence the treatment outcomes. In this article, we are going to review the basic concepts and the results of previous clinical trials on sequential therapy.
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