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Management of the Most Common Functional Gastrointestinal Disorders in Infancy: The Middle East Expert Consensus

Indrio F, Enninger A, Aldekhail W, Al-Ghanem G, Al-Hussaini A, Al-Hussaini B, Al-Refaee F, Al-Said K, Eid B, Faysal W, Hijazeen R, M.A. Isa H, Onkarappa D, Rawashdeh M, Rohani P, Sokhn M

The occurrence of functional gastrointestinal disorders (FGIDs) is a formidable challenge for infants, parents, and healthcare professionals. Although data from the Middle East are scarce, experts consider FGIDs a prevalent...
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Probiotics in the Prevention and Treatment of Necrotizing Enterocolitis

Seghesio E, Geyter CD, Vandenplas Y

Necrotizing enterocolitis (NEC) is a disease with high morbidity and mortality that occurs mainly in premature born infants. The pathophysiologic mechanisms indicate that gastrointestinal dysbiosis is a major risk factor....
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Effects of Lactobacillus acidophilus HY7032 and Lactobacillus reuteri HY7506 isolated from dog feces on welfare and hair in companion dogs

Lee HJ, Lee SW

Precise combinations of probiotics can be useful in dog nutrition, treatment and care. Also, host specificity must be considered in order to increase the effectiveness of probiotics. In this study,...
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Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota

Shin DY, Park J, Yi DY

Background: Human breast milk (HBM) contains optimal nutrients for infant growth. Probiotics are used to prevent disease and, when taken by the mother, they may affect infant microbiome as well as...
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Therapeutic Potential of Escherichia coli Nissle 1917 in Clinically Remission-attained Ulcerative Colitis Patients: A Hospital-based Cohort Study

Oh GM, Moon W, Seo KI, Jung K, Kim JH, Kim SE, Park MI, Park SJ

Background/Aims: Escherichia coli Nissle 1917 (EcN) alone therapy is as effective as mesalamine in inducing and maintaining remission in ulcerative colitis (UC). The efficacy and safety of EcN in combination...
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Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

Lee NY, Shin MJ, Youn GS, Yoon SJ, Choi YR, Kim HS, Gupta H, Han SH, Kim BK, Lee DY, Park TS, Sung H, Kim BY, Suk KT

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There is a paucity of research on which strains of gut microbiota affect the progression of NAFLD. This study...
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Probiotics for treatment of nonalcoholic fatty liver disease: It is worth a try

Ren TY, Li XY, Fan JG

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A Case Report of Saccharomyces cerevisiae Fungemia in a Premature Infant Following Probiotic Treatment

Lee J, Kim H, Lee HK, Park YJ

Probiotics are used to restore and maintain the healthy intestinal microflora. Although Saccharomyces cerevisiae (SC) is considered as a non-pathogenic yeast, administration of SC as a probiotic is associated with...
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Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis

Kluijfhout S, Trieu TV, Vandenplas Y

Purpose: Some probiotic strains reduce the duration of acute diarrhea. Because of strain and product specificity, each product needs to be supported by clinical data. This study aimed to test...
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Combined Effects of Lactobacillus rhamnosus and Egg Oral Immunotherapy in a Mouse Model of Egg Allergy

Kim BG, Kim JN, Jang AS, Shin M

Purpose: Recent clinical trials have successfully used oral immunotherapy (OIT) to treat food allergies. Probiotics have immunomodulatory effects by balancing Th1/Th2 immunity and enhancing regulatory T-cell activity. In this study,...
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Can a Synbiotic Supplementation Contribute to Decreasing Anti-Tissue Transglutaminase Levels in Children with Potential Celiac Disease?

Demiroren K

Purpose: Synbiotics can alleviate some intestinal pathologies or prevent trigger mechanisms for some diseases such as celiac disease (CD). If patients with high levels of anti-tissue transglutaminase (anti-tTG) immunoglobulin A...
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Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study

Lim S, Moon JH, Shin CM, Jeong D, Kim B

Background: The increased prevalence of obesity has led to increases in the prevalence of chronic diseases worldwide. There is interest whether probiotics have an effect on obesity, but the effectiveness...
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Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy

Chang YW, Park YM, Oh CH, Oh SJ, Cho JH, Kim JW, Jang JY

Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether...
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Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice

Wang W, Xu AL, Li ZC, Li Y, Xu SF, Sang HC, Zhi F

Background: Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men. Methods: Probiotics with lipid-lowering function were...
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Effects of Lactobacillus pentosus in Children with Allergen-Sensitized Atopic Dermatitis

Ahn SH, Yoon W, Lee SY, Shin HS, Lim MY, Nam YD, Yoo Y

Background: Recent studies have shown that oral administration of probiotics may improve the immune imbalance caused by dysbiosis of the gut microbiome in atopic dermatitis (AD). This study aimed to...
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Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis

Lee KI, Yun T, Ham J, Lee WK, Kang JH, Yang MP, Kang BT

This study assessed the effects of probiotics in canine atopic dermatitis (AD). We enrolled 11 client-owned dogs with AD and randomly allocated them to two groups. The probiotics group (n...
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The effects of three novel probiotics isolated from the Korean fermented food Kimchi on the stress-induced defecation of rats

Kim MJ, Min YW, Lee C, Jang YS, Kim CH, Chang DK

Purpose: The interest in novel probiotics that improve symptoms of irritable bowel syndrome (IBS) has been growing trend. This study aims to investigate the probiotic effect of three kinds of...
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Effects of Novel Probiotics in a Murine Model of Irritable Bowel Syndrome

Chung HG, Min YW, Lee C, Hong SN, Won JY, Jang JA, Kim CH, Chang DK

BACKGROUND/AIMS: Dysbiosis is an important factor in the pathogenesis of irritable bowel syndrome (IBS). Several studies have reported promising results using probiotics for the treatment of IBS. This study evaluated...
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Inhibitory effect of the probiotic bacteria, Weissella cibaria CMU on halitosis: a randomized placebo-controlled study

Kim DH, Kang MS, Yeu JE, Lee MG, Cho JW

Objectives: Previous studies have suggested that the lactic acid bacterium, Weissella cibaria CMU has beneficial effects on halitosis, but its precise effects have not been evaluated in human subjects. We...
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Changes in the Crohn’s Disease Activity Index and Safety of Administering Saccharomyces Boulardii in Patients with Crohn’s Disease in Clinical Remission: A Single Hospital-based Retrospective Cohort Study

Oh GM, Moon W, Seo KI, Jung K, Kim JH, Kim SE, Park MI, Park SJ

Background/Aims: Crohn’s disease (CD) is characterized by uncontrolled inflammation of the intestine. Saccharomyces Boulardii (S. boulardii), a probiotic, stabilizes the intestinal wall. This study examined the changes in the...
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