J Stroke.
2018 Sep;20(3):281-291. 10.5853/jos.2018.02537.
Percutaneous Left Atrial Appendage Occlusion for the Prevention of Stroke in Patients with Atrial Fibrillation: Review and Critical Appraisal
- Affiliations
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- 1Department of Neurology and Neurogeriatry, Johannes Wesling Medical Center Minden, University Clinic RUB, Minden, Germany. peter.schellinger@muehlenkreiskliniken.de
- 2Second Department of Neurology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
- 3Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA.
- 4Department of Neurology, Frankfurt Hoechst Hospital, Frankfurt, Germany.
- 5Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
- 6Department of Neurology, Essen University Hospital, Essen, Germany.
- KMID: 2428764
- DOI: http://doi.org/10.5853/jos.2018.02537
Abstract
- The authors review the current status of percutaneous left atrial appendage (LAA) occlusion therapy in patients with atrial fibrillation with the goal to prevent ischemic stroke and systemic embolism and to reduce oral anticoagulation associated bleeding. While we cover the historical and also surgical background, and all tested devices, the main focus rests on the single currently U.S. Food and Drug Administration (FDA) approved LAA occluder, the WATCHMAN device, and its approval process. The authors also give a critical appraisal beyond the review of mere facts, trying to put the current data into perspective.
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