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What is the Best Choice for Urate-lowering Therapy for Korean?

Cheon YH, Song JS

Gout is one of the most common forms of acute inflammatory arthritis caused by long-standing hyperuricemia. Various clinical and epidemiological studies have demonstrated that uric acid, which is strongly associated...
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Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy

Jeong S, Park SH

Immune checkpoint inhibitors (ICIs), including anti-PD-1 and anti-CTLA-4 therapeutic agents, are now approved by the Food and Drug Administration for treatment of various types of cancer. However, the therapeutic efficacy...
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Analysis of individual case safety reports of drug-induced anaphylaxis to the Korea Adverse Event Reporting System

Cho MK, Moon M, Kim HH, Kang DY, Lee JY, Cho SH, Kang HR

PURPOSE: To identify causative agents of the drug-induced anaphylaxis (DIA) by using the Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System (KIDS-KAERS) database (Ministry of Food...
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Real-Life Effectiveness and Tolerability of Perampanel in Pediatric Patients Aged 4 Years or Older with Epilepsy: A Korean National Multicenter Study

Hwang SK, Lee YJ, Nam SO, Kim WS, Kim JS, Kim SJ, Lee YJ, Kwon S

BACKGROUND AND PURPOSE: The US Food and Drug Administration approval for perampanel has only recently been expanded to patients as young as 4 years, and so there have been few...
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‘Testosterone Boosting’ Supplements Composition and Claims Are not Supported by the Academic Literature

Clemesha C, Thaker H, Samplaski

PURPOSE: Men take testosterone (T) boosting supplements to naturally improve T levels. We evaluated the composition and advertised claims of “T boosting” supplements, and supporting published evidence. MATERIALS AND METHODS: Fifty...
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The Role of Anti-Obesity Medication in Prevention of Diabetes and Its Complications

Oh TJ

Diabetes is prevalent in obese population, and obesity management is the first step in preventing diabetes. Traditionally, lifestyle modification including reduced-calorie diet, physical activity, and behavior intervention is the core...
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The Occurrence and Risk Assessment of Exposure to Aflatoxin M₁ in Ultra-High Temperature and Pasteurized Milk in Hamadan Province of Iran

Nejad AS, Heshmati A, Ghiasvand

OBJECTIVES: Aflatoxins are a category of poisonous compounds found in most plants, milk and dairy products. The present research was carried out to detect the presence of aflatoxin M₁ (AFM₁)...
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Quantitative Analysis of Metal Contents in Korean Herbs and Herbal Products to Give Advice for Metal Allergic Patient

Choi MJ, Byun JY, Choi HY, Choi YW

BACKGROUND: Herbs have been used worldwide as complementary and alternative medicines. In Korea, herbs for medical purpose are strictly controlled by the Korea Food and Drug Administration (KFDA). But it...
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In-line Filtration in Parenteral Nutrition

Kim E, Seol EM

Metabolic abnormalities and catheter-related infections are common complications of parenteral nutrition (PN). Particulate contamination is a catheter-related complication can occur when administering PN: mixing the electrolytes, trace elements, vitamins into...
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Improved Bulbar Function in Amyotrophic Lateral Sclerosis after Nuedexta (Dextromethorphan and Quinidine) Treatment

Cho HJ, Park JM, Park JS

Nuedexta (dextromethorphan and quinidine) is an Food and Drug Administration approved medication for pseudobulbar affect. Interestingly, this drug was recently reported to improve speech, swallowing, and the ability to handle...
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A Primer on Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Medically Refractory Epilepsy

Lee EJ, Kalia SK, Hong SH

Epilepsy surgery that eliminates the epileptogenic focus or disconnects the epileptic network has the potential to significantly improve seizure control in patients with medically intractable epilepsy. Magnetic resonance-guided laser interstitial...
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Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future

Jeon GW

Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been...
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Effects of Thiazolidinedione and New Antidiabetic Agents on Stroke

Ahn CH, Lim S

Patients with hyperglycemia are at a high risk of cardio- and cerebrovascular diseases. Diabetes patients also have poor outcomes after cerebrovascular disease development. Several classes of drugs are used for...
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Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma

Chae H, Yoon DH

CD19 chimeric antigen receptor T-cell (CAR-T) therapy, a genetically engineered cell therapy, showed unprecedented efficacy in the treatment of relapsed or refractory diffuse large B-cell lymphoma. Two agents, axicabtagene ciloleucel...
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Bronchial Thermoplasty in Patients with Severe Uncontrolled Asthma: First Korean Cases

Kang J, Cho YS, Choi DK, Lee JS, Oh YM, Lee SD, Lee SW

Bronchial thermoplasty is a nonpharmacological treatment for severe asthma that delivers thermal energy to the bronchial walls and reduces hypertrophied smooth muscle mass. Previous studies have shown its efficacy and...
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Robot-assisted surgery in gynecology

Chung YJ, Kim MR

The development of robotic technology has facilitated the application of minimally invasive techniques for complex gynecologic surgery. Robot-assisted gynecologic surgery has grown exponentially since receiving Food and Drug Administration approval...
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Issues on carcinogen contaminated antihypertensive drugs and constructing drug safety management system

Park BJ

European Medicines Agency withdrew valsartan from European market in July 2018 because it was contaminated with carcinogen, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA). Medicines and Healthcare Products Regulatory Agency also found...
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Delafloxacin, a New Miracle in Antibiotics Armamentarium for Bacterial Infections

Rahman MS, Koh YS

The persistent antibiotics resistant issue has emerged as an influencing factor to deteriorate community health. So, new antibiotics development is urgent for the treatment of bacterial infections. Alternatively, delafloxacin is...
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Development of Squamous Cell Carcinoma from Actinic Keratosis after Ingenol Mebutate Gel Use

Choi JW, Suh DW, Lew BL, Sim WY

  • KMID: 2440728
  • Korean J Dermatol.
  • 2019 Feb;57(2):89-93.
Ingenol mebutate gel is a new short-term topical treatment approved in 2012 by the US Food and Drug Administration and its efficacy has been demonstrated in numerous studies. To report...
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Signal Detection for Cardiovascular Adverse Events of DPP-4 Inhibitors Using the Korea Adverse Event Reporting System Database, 2008–2016

Yi H, Lee JH, Shin JY

PURPOSE: Cardiovascular adverse events (AEs) after use of dipeptidyl peptidase-4 (DPP4) inhibitors have been reported and suspected since the launch of DPP-4 inhibitors in 2006. However, few studies have investigated...
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