J Pathol Transl Med.  2018 Nov;52(6):420-424. 10.4132/jptm.2018.03.29.

Collagenous Spherulosis Associated with Lobular Carcinoma In Situ of the Breast: Two Case Reports

• Kim GE
• Kim NI
• Lee JS
• Park MH

• KMID: 2427526
• DOI: http://doi.org/10.4132/jptm.2018.03.29

Abstract

No abstract available.

MeSH Terms

Breast*
Carcinoma, Lobular*
Collagen*
Collagen

Figure

• 

  Fig. 1. Microscopic and immunohistochemical findings of case 1 collagenous spherulosis (CS) associated with lobular carcinoma in situ (LCIS), classical type. (A) In LCIS, enlarged lobules are seen. (B) The neoplastic cells of LCIS show loss of cohesion. (C) Cribriform proliferation with spherules containing cellular fibrillar components is seen. (D) LCIS cells colonize CS. (E) LCIS cells stain negative for E-cadherin, and the residual cells of CS stain positive. (F) Myoepithelial cells within CS with LCIS show calponin immunoreactivity. (G) Basement membrane-like components within spherules are highlighted by laminin immunostain. (H) CS with LCIS is negative for c-Kit.

• 

  Fig. 2. Microscopic and immunohistochemical findings of case 2 collagenous spherulosis (CS) associated with lobular carcinoma in situ (LCIS), pleomorphic type. (A) The LCIS area shows enlarged lobular glands and intraepithelial growth pattern. (B) In contrast to case 1, the neoplastic cells contain more abundant cytoplasm and pleomorphic nuclei with occasional nucleoli. (C) A cribriform pattern of CS is characterized by cystic spaces containing basophilic fibrillar components. (D) CS with LCIS retains cribriform spaces, which contain cellular fibrillar components. (E) LCIS cells within the spherule show loss of E-cadherin expression. (F, G) The cells surrounding the spherules are positive for calpoinin and p63. (H) CS with LCIS is negative for c-Kit.

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