J Korean Med Assoc.
2018 Nov;61(11):670-677. 10.5124/jkma.2018.61.11.670.
Pathophysiology and new treatment of itch
- Affiliations
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- 1Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. hyeonekim@gmail.com
- KMID: 2426477
- DOI: http://doi.org/10.5124/jkma.2018.61.11.670
Abstract
- Many of the patients visit the doctors because of itching sensation. Itching is an unpleasant sensation. In the epidermal keratinocytes, various neurotransmitters and receptors are related itching. The itch signal is mainly transmitted through the lateral spinal ganglion-derived nerve fibers extending to the lower epidermis. Many mediators such as histamine are involved in the itching pathway. It can be helpful in the treatment of patients having itching sensation with a lot of new therapies from the basic medication such as antihistamines. Also, many drugs are currently under study.
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