Korean J Intern Med.  2018 Nov;33(6):1103-1110. 10.3904/kjim.2017.133.

Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group

• Park JW
• Choi JS
• Han KJ
• Lee SH
• Kim EJ
• Cho JH

• KMID: 2426394
• DOI: http://doi.org/10.3904/kjim.2017.133

Abstract

BACKGROUND/AIMS
Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytokine polymorphisms and AP as pilot research in a Korean ethnic group.
METHODS
Patients who had been diagnosed with AP were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Single-nucleotide polymorphisms (SNPs) of the interleukin 1β (IL1B), interleukin 1 receptor antagonist (IL1RN), and tumor necrosis factor α (TNFA) genes of patients with AP were compared to those of normal controls.
RESULTS
Between January 2011 and January 2013, a total of 65 subjects were enrolled (40 patients with AP vs. 25 healthy controls). One intronic SNP (IL1RN −1129T>C, rs4251961) was significantly associated with the risk of AP (odds ratio, 0.304; 95% confidence interval, 0.095 to 0.967; p = 0.043). However, in our study, AP was not found to be associated with polymorphisms in the promoter regions of inflammatory cytokine genes, including IL1B (−118C>T, c47+242C>T, +3954C/T, and −598T>C) and TNFA (−1211T>C, −1043C>A, −1037C>T, −488G>A, and −418G>A).
CONCLUSIONS
IL1RN −1129T>C (rs4251961) genotypes might be associated with a significant increase of AP risk in a Korean ethnic group.

Keyword

Pancreatitis; Polymorphism, single nucleotide; Interleukins; Tumor necrosis factor-alpha

MeSH Terms

Asian Continental Ancestry Group
DNA
Epidemiologic Studies
Ethnic Groups*
Genotype
Humans
Interleukins
Introns
Pancreatitis*
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Prospective Studies
Receptors, Interleukin-1
Sequence Analysis, DNA
Tumor Necrosis Factor-alpha
DNA
Interleukins
Receptors, Interleukin-1
Tumor Necrosis Factor-alpha