J Stroke.  2018 Jan;20(1):57-70. 10.5853/jos.2017.02796.

Treatments to Promote Neural Repair after Stroke

• Cramer SC

• KMID: 2424437
• DOI: http://doi.org/10.5853/jos.2017.02796

Abstract

Stroke remains a major cause of human disability worldwide. In parallel with advances in acute stroke interventions, new therapies are under development that target restorative processes. Such therapies have a treatment time window measured in days, weeks, or longer and so have the advantage that they may be accessible by a majority of patients. Several categories of restorative therapy have been studied and are reviewed herein, including drugs, growth factors, monoclonal antibodies, activity-related therapies including telerehabilitation, and a host of devices such as those related to brain stimulation or robotics. Many patients with stroke do not receive acute stroke therapies or receive them and do not derive benefit, often surviving for years thereafter. Therapies based on neural repair hold the promise of providing additional treatment options to a majority of patients with stroke.

Keyword

Stroke; Neuronal plasticity; Stroke rehabilitation; Recovery of function; Telerehabilitation

MeSH Terms

Antibodies, Monoclonal
Brain
Humans
Intercellular Signaling Peptides and Proteins
Neuronal Plasticity
Recovery of Function
Robotics
Stroke*
Telerehabilitation
Antibodies, Monoclonal
Intercellular Signaling Peptides and Proteins