Immune Netw.  2018 Oct;18(5):e34. 10.4110/in.2018.18.e34.

Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses

• Park C
• Kim TJ

• KMID: 2424200
• DOI: http://doi.org/10.4110/in.2018.18.e34

Abstract

In addition to T cell-dependent (TD) Ab responses, T cells can also regulate T cell-independent (TI) B cell responses in the absence of a specific major histocompatibility complex (MHC) class II and antigenic peptide-based interaction between T and B cells. The elucidation of T cells capable of supporting TI Ab responses is important for understanding the cellular mechanism of different types of TI Ab responses. Natural killer T (NKT) cells represent 1 type of helper T cells involved in TI Ab responses and more candidate helper T cells responsible for TI Ab responses may also include γδ T cells and recently reported B-1 helper CD4⁺ T cells. Marginal zone (MZ) B and B-1 cells, 2 major innate-like B cell subsets considered to function independently of T cells, interact with innate-like T cells. Whereas MZ B and NKT cells interact mutually for a rapid response to blood-borne infection, peritoneal memory phenotype CD49d(high)CD4⁺ T cells support natural Ab secretion by B-1 cells. Here the role of innate-like T cells in the so-called TI Ab response is discussed. To accommodate the involvement of T cells in the TI Ab responses, we suggest an expanded classification of TD Ab responses that incorporate cognate and non-cognate B cell help by innate-like T cells.

Keyword

Antigen-antibody reactions; Innate lymphocytes; Natural killer T-cells; B-1 lymphocyte

MeSH Terms

Antibody Formation*
Antigen-Antibody Reactions
B-Lymphocyte Subsets
B-Lymphocytes
Classification
Major Histocompatibility Complex
Memory
Natural Killer T-Cells
Phenotype
T-Lymphocytes*
T-Lymphocytes, Helper-Inducer