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Analysis of Circulating B-1 B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus

Baik SJ, Lee J, Lee YH

OBJECTIVES: To define the abnormalities in homeostasis of B-1 B lymphocytes compartments in human SLE. METHODS: Perpheral blood was obtained from 7 patients with untreated active SLE patients and same patients...
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Modulatory effects of chitosan adipate on the T and B lymphocyte subsets in mice

Obminska-Mrukowicz B, Szczypka M, Gaweda B

This study examined the subsets of T lymphocytes in the thymus, spleen and mesenteric lymph nodes as well as the subsets of B lymphocytes in the spleen and mesenteric lymph nodes in mice...
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Normal Lymphocyte Subpopulation of the Spleen is Altered after Peripheral Nerve Injury in Mice

You JH, Song HK, Jeong DC, Hyoun BD

BACKGROUND: Chronic neuropathic pain is often associated with altered immune function and the modulated immune cell response play a role in neuropathic pain by experimental nerve injury. In order to...
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Frequency and Distribution of Lymphocytes Related to Innate Immunity in Palatine Tonsils and Adenoids

Roh JL, Seong WJ, Sung MW, Lee DW, Park BJ, Park SW, Kim KH

  • KMID: 2074440
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 Oct;44(10):1073-1079.
BACKGROUND AND OBJECTIVES: Palatine tonsils and adenoids protect the human body from various pathogens entering through the pharyngeal mucosa. Many studies have been performed for the specific immunity, but the...
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Single-color Multitarget Flow Cytometry Using Monoclonal Antibodies Labeled with Different Intensities of the Same Fluorochrome

Park J, Han K

BACKGROUND: We developed a single-color multitarget flow cytometry (SM-FC) assay, a single-tube assay with graded mean fluorescence intensities (MFIs). We evaluated the repeatability of SM-FC, and its correlation with multicolor...
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Expansion and Sub-Classification of T Cell-Dependent Antibody Responses to Encompass the Role of Innate-Like T Cells in Antibody Responses

Park C, Kim TJ

In addition to T cell-dependent (TD) Ab responses, T cells can also regulate T cell-independent (TI) B cell responses in the absence of a specific major histocompatibility complex (MHC) class...
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Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis

Luo J, Guo H, Liu Z, Peng T, Hu X, Han M, Yang X, Zhou X, Li H

PURPOSE: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic...
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N-Region Addition in Immunoglobulin Kappa Light Chains in B Cell Subsets in Rheumatoid Arthritis: Evidence for Over-expression of TDT in B Lineage

Lee CW, Bridges SL

BACKGROUND: Unusually high amounts of N region addition and CDR3 length diversity were found in immunoglobulin (Ig) light chain Vk and Jk joins in patients with rheumatoid arthritis (RA). We...
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B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

Min YG, Park C, Kwon YN, Shin JY, Sung JJ, Hong YH

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that...
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Characterization of FSC(high) Memory B Cells from Patients with Active Systemic Lupus Erythematosus

Jhun JY, Kim YJ, Ju JH, Park SH, Chang SH, Kim HY

OBJECTIVE: To determine phenotypic and functional characteristics of memory B cells in patients with systemic lupus erythematosus (SLE). METHODS: The percentage of memory B cell subsets in peripheral blood mononuclear...
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Human B1 Cells are the Main Blood Group A-Specific B Cells That Have a Moderate Correlation With Anti-A Antibody Titer

Xu Y, Lee JG, Yan JJ, Ryu JH, Xu S, Yang J

BACKGROUND: Anti-carbohydrate antibody responses, including those of anti-blood group ABO antibodies, are yet to be thoroughly studied in humans. Because anti-ABO antibody-mediated rejection is a key hurdle in ABO-incompatible transplantation,...
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B cell-associated immune profiles in patients with end-stage renal disease (ESRD)

Kim KW, Chung BH, Jeon EJ, Kim BM, Choi BS, Park CW, Kim YS, Cho SG, Cho ML, Yang CW

  • KMID: 1387357
  • Exp Mol Med.
  • 2012 Aug;44(8):465-472.
Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect...
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Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors

Yu JH, Kim KW, Kim BM, Chung BH, Cho ML, Choi BS, Park CW, Kim YS, Yang CW

BACKGROUND/AIMS: Sirolimus (SRL) is a promising immunosuppressant replacingcalcineurin inhibitors (CNIs). This study was performed to evaluate the safetyand immunologic benefits of conversion to SRL in stable kidney transplant (KT)recipients exposed...
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Down-regulation of Membrane Bound CD27 Expression Mediated by Protein Kinase C-beta and Protein Kinase C-delta in B Cells

Lee SY, Min JK, Cho ML, Moon YM, Kim KW, Min SY, Cho YG, Yoon CH, Park SH, Kim HY

  • KMID: 2202281
  • J Korean Rheum Assoc.
  • 2006 Mar;13(1):33-45.
OBJECTIVE: CD27 is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on T, B, and NK cells. The signaling via CD27 plays pivotal roles in...
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IL-10 is Predominantly Produced by CD19(low)CD5(+) Regulatory B Cell Subpopulation: Characterisation of CD19 (high) and CD19(low) Subpopulations of CD5(+) B cells

Lee JH, Noh J, Noh G, Choi WS, Lee SS

IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10,...
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