Asia Pac Allergy.  2018 Oct;8(4):e37. 10.5415/apallergy.2018.8.e37.

A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin)

• Takai H
• Kato I
• Mitsunaga
• Hara M
• Kodama T
• Kanazawa M
• Terai M

• KMID: 2423988
• DOI: http://doi.org/10.5415/apallergy.2018.8.e37

Abstract

Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication.

Keyword

Anaphylaxis; Anaphylactic shock; Drug allergy; Asverin; Tipepidine hibenzate; Child

MeSH Terms

Anaphylaxis*
Child
Common Cold
Consciousness
Cough
Drug Hypersensitivity
Erythema
Humans
Hypotension
Male
Respiratory Sounds
Skin
Urticaria
Vomiting