J Vet Sci.  2023 Nov;24(6):e77. 10.4142/jvs.23188.

Simultaneous hypersensitivity reactions to trimethoprimsulfamethoxazole and amoxicillinclavulanate in a dog

• Jeong Y
• Kim YH
• Ahn JO
• Chung JY

• KMID: 2548989
• DOI: http://doi.org/10.4142/jvs.23188

Abstract

Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillinclavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.

Keyword

Case reports; immune thrombocytopenia; adverse drug reaction; anaphylactic shock; antibiotics