Anesth Pain Med.  2015 Oct;10(4):288-290. 10.17085/apm.2015.10.4.288.

A suspected case of sugammadex-induced anaphylactic shock: A case report

• Hwang MH
• Won YJ
• Lee IO
• Koo EH
• Jung WJ

• KMID: 2148015
• DOI: http://doi.org/10.17085/apm.2015.10.4.288

Abstract

We describe a case involving a 69-year-old woman who developed anaphylatic shock caused by a clinical dose of sugammadex (2 mg/kg, 100 mg intravenously) 5 minutes after its administration. She developed redness and welts all over her body, and complained of an oropharyngeal itching sensation with dyspnea and dizziness. Her vital signs were closely monitored. She also experienced a sudden onset of hypotension (from 110/70 to 49/40 mmHg) and tachycardia (from 75 to 120 bpm). We diagnosed anaphylactic shock on the basis of these clinical manifestations. After 20 min of traditional treatment (hydration, ephedrine, cortisol, and phenylephrine), her vital signs returned to normal. No postoperative complications were evident, and the patient was discharged from the hospital. Although the prevalence of anaphylactic reactions to sugammadex is rare, physicians using sugammadex should be aware of the possibility of sugammadex-induced anaphylaxis.

Keyword

Anaphylactic shock; Hypersensitivity; Sugammadex

MeSH Terms

Aged
Anaphylaxis*
Dizziness
Dyspnea
Ephedrine
Female
Humans
Hydrocortisone
Hypersensitivity
Hypotension
Postoperative Complications
Prevalence
Pruritus
Sensation
Shock
Tachycardia
Vital Signs
Ephedrine
Hydrocortisone