Tissue Eng Regen Med.
2018 Oct;15(5):559-574. 10.1007/s13770-018-0158-2.
Injectable Biomaterials in Plastic and Reconstructive Surgery: A Review of the Current Status
- Affiliations
-
- 1Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA.
- 2Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.
- 3Department of Biomedical Sciences, Chonnam National University Medical School, 160 Baekseo-ro, Gwangju 61469, Republic of Korea.
- 4Research Institute for Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. chocs@snu.ac.kr
- KMID: 2422671
- DOI: http://doi.org/10.1007/s13770-018-0158-2
Abstract
- BACKGROUND
Injectable biomaterials have attracted increasing attention for volume restoration and tissue regeneration. The main aim of this review is to discuss the current status of the injectable biomaterials for correction of tissue defects in plastic and reconstructive surgery.
METHODS
Requirements of injectable biomaterials, mechanism of in situ gelation, characteristics, and the combinational usage of adipose-derived stem cells (ADSCs) and growth factors were reviewed.
RESULTS
The ideal injectable biomaterials should be biocompatible, non-toxic, easy to use, and cost-effective. Additionally, it should possess adequate mechanical properties and stability. In situ gelation method includes physical, chemical, enzymatic and photo-initiated methods. Natural and synthetic biomaterials carry their pros and cons due to their inherent properties. The combined use of ADSCs and growth factors provides enhanced potential for adipose tissue regeneration.
CONCLUSION
The usage of injectable biomaterials has been increasing for the tissue restoration and regeneration. The future of incorporating ADSCs and growth factors into the injectable biomaterials is promising.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Trend of Biomaterials in Facial Plastic and Reconstructive Surgery
- The peer review system of Archives of Plastic Surgery: Current status and plans for improvement
- Tissue Bank : Current Status and Development in the Field of Plastic Surgery in Korea
- A note on the current review process of Archives of Plastic Surgery
- The History and Future of Plastic and Reconstructive Surgery
