Korean J Fam Med.
2018 Sep;39(5):295-299. 10.4082/kjfm.17.0034.
Association between Serum Uric Acid and Oxidative Stress in Korean Adults
- Affiliations
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- 1Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. sbpark@ajou.ac.kr
- KMID: 2422109
- DOI: http://doi.org/10.4082/kjfm.17.0034
Abstract
- BACKGROUND
Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults.
METHODS
The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined.
RESULTS
Higher serum UA levels were associated with decreased levels of d-ROMs (P < 0.05). The UA levels were positively associated with BAP levels (P < 0.001).
CONCLUSION
Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans.
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