J Neurogastroenterol Motil.
2018 Jan;24(1):107-118. 10.5056/jnm17038.
White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome
- Affiliations
-
- 1School of Computer and Communication Engineering, Zhengzhou University of Light Industry, Zhengzhou, China.
- 2First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
- 3First Affiliated Hospital of Yan'an University, Yan'an, China.
- 4Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China. profzmmri@gmail.com
- KMID: 2417278
- DOI: http://doi.org/10.5056/jnm17038
Abstract
- BACKGROUND/AIMS
The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C.
METHODS
The voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics. The correlations between diffusive parameters and clinical symptoms were evaluated using a Pearson's correlation.
RESULTS
In comparison to healthy controls, FC patients showed a decrease of fractional anisotropy (FA) and an increase of radial diffusivity (RD) in multiple major fibers encompassing the corpus callosum (CC, P = 0.001 at peak), external capsule (P = 0.002 at peak), corona radiata (CR, P = 0.001 at peak), and superior longitudinal fasciculus (SLF, P = 0.002 at peak). In contrast, IBS-C patients showed FA and RD aberrations in the CC (P = 0.048 at peak). Moreover, the direct comparison between FC and IBS-C showed only RD differences in the CR and SLF. In addition, FA and RD in the CC were significantly associated with abdominal pain for all patients, whereas FA in CR (P = 0.016) and SLF (P = 0.040) were significantly associated with the length of time per attempt and incomplete evacuation separately for FC patients.
CONCLUSION
These results may improve our understanding of the pathophysiological mechanisms underlying different types of constipation.
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