J Korean Radiol Soc.  1992 Jun;28(3):448-452.

Radiologic evaluation of adriamycin induced toxic cardiomyopathy in childhood leukemia

• Kim YJ
• Moon YH
• Kang KJ
• Kim OH
• Kim CY
• Bahk YW

Abstract

The cardiomyopathy associated with Adriamycin is frequently fatal and full clinical recovery is uncommon. To evaluate the radiological manifestation and the outcome of Adriamycin induced cardiac toxicity, we retrospectively reviewed the serial chest X-ray films of children treated with Adriamycin. Among 154 children with leukemia, fourteen patients developed clinical and radiologic evidence of congestive heart failure(CHF), Six out of 14(43%) died of CHF within 2 weeks after attack and eight children survived after their acute episodes of CHF, were controlled following digoxin and diuretic therapy. Despite the improving clinical evidence of heart failure, the follow-up chest roentgenograms of these 8 children showed definite cardiomegaly as compared with the pre-treatment chest X-ray. Three children among 8 had minimal cardiomegaly and the remaining five children showed persistent, marked cardiomegaly during the period of 9-25 months of follow up. In summary, when CHF develops during chemotherapy in leukemic children, the possibility of Adriamycin induced cardiac toxicity should be suspected. Our findings showed that persistence of cardiomegaly represented significant cardiomyopathy despite clinical improvement of CHF.

MeSH Terms

Cardiomegaly
Cardiomyopathies*
Cardiotoxicity
Child
Digoxin
Doxorubicin*
Drug Therapy
Estrogens, Conjugated (USP)
Follow-Up Studies
Heart
Heart Failure
Humans
Leukemia*
Retrospective Studies
Thorax
X-Ray Film
Digoxin
Doxorubicin
Estrogens, Conjugated (USP)