Nat Prod Sci.  2018 Jun;24(2):93-98. 10.20307/nps.2018.24.2.93.

Cytotoxic Triterpenoids from the Fruits of Ligustrum japonicum

Affiliations
  • 1College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. bsmin@cu.ac.kr, weonky@cu.ac.kr

Abstract

Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 - 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC50 values of 5.5 µM, and moderate effects on HL-60 cells with ICâ‚…â‚€ values of 55.9 µM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with ICâ‚…â‚€ value of 55.0 and 68.8 µM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with ICâ‚…â‚€ value of 63.9 µM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.

Keyword

Ligustrum japonicum; Oleaceae; Triterpenoids; Cytotoxic activity

MeSH Terms

Antineoplastic Agents
Fruit*
HL-60 Cells
Humans
Inhibitory Concentration 50
Ligustrum*
Mass Screening
Nerium
Oleaceae
Phytochemicals
Plants, Medicinal
Antineoplastic Agents
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