Nat Prod Sci.
2021 Mar;27(1):18-27. 10.20307/nps.2021.27.1.18.
Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
- Affiliations
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- 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65145, Indonesia
- 2Academy of Pharmacy of Putra Indonesia, Malang 65123, Indonesia
- 3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
- 4Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60286, Indonesia
- 5Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia
- 6Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.
- KMID: 2514906
- DOI: http://doi.org/10.20307/nps.2021.27.1.18
Abstract
- Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC 50 values of 16.8µM
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