Nat Prod Sci.
2022 Mar;28(1):6-12. 10.20307/nps.2022.28.1.6.
Sesquiterpenoids from the Stem Bark of Aglaia grandis
- Affiliations
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- 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia
- 2Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia
- 3School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia
- 4Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.
- KMID: 2528073
- DOI: http://doi.org/10.20307/nps.2022.28.1.6
Abstract
- Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR ( 1 H, 13 C, DEPT 135°, HMQC, HMBC, 1 H- 1 H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
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