Nat Prod Sci.  2022 Mar;28(1):1-5. 10.20307/nps.2022.28.1.1.

Anti-inflammatory and Neurotrophic 2H-1-Benzopyran Derivatives of Chaenomeles sinensis

• Harneti D
• Permatasari AA
• Anisshabira A
• Naini AA
• N
• Mayanti T
• Maharani R
• Safari A
• Hidayat AT
• Farabi K
• Supratman U
• Azmi MN
• Shiono Y

• KMID: 2528072
• DOI: http://doi.org/10.20307/nps.2022.28.1.1

Abstract

Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR ( ¹ H, ¹³ C, DEPT 135°, HMQC, HMBC, ¹ H- ¹ H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.

Keyword

Chaenomeles sinensis; 2H-1-Benzopyran Derivatives; anti-neuroinflammation; neurotrophic activity