Ann Geriatr Med Res.  2016 Dec;20(4):190-194. 10.4235/agmr.2016.20.4.190.

Clinical Factors Associated With Trabecular Bone Score in Koreans: A Retrospective Study

• Chung EH
• Lee SH
• Kim JH
• Park HJ
• Min HY
• Kim SH
• Yun JM
• Cho BL

• KMID: 2415678
• DOI: http://doi.org/10.4235/agmr.2016.20.4.190

Abstract

BACKGROUND
The objective of our study was to examine the clinical factors associated with bone microarchitecture in Koreans. To the best of our knowledge, only a few studies have investigated these factors.
METHODS
Data from patients who underwent a dual-energy X-ray absorptiometry scan at Seoul National University Hospital health promotion center between November 2014 and March 2015 were collected. The study population was divided into 2 groups, according to the patient's trabecular bone score (TBS) as follows: normal TBS ≥1.35 (n=700) and low TBS <1.35 (n=154). Intergroup comparison was carried out using the Student t-test and chi-square test. Logistic regression analysis, adjusted for age and body mass index (BMI), was applied to investigate the factors associated with TBS.
RESULTS
Data from 854 men and women were analyzed. Our results showed that TBS was inversely associated with age, BMI, waist circumference, serum phosphorus level (P), serum alkaline phosphatase level (ALP), serum C-terminal telopeptide (CTX), serum triglycerides (TG), serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood count (WBC). Bone mineral density (BMD) was positively related to TBS. BMD, waist circumference, and serum ALP had an association with TBS in both men and women, after adjusting for age and BMI.
CONCLUSION
Our findings suggest that obese patients (especially those with abdominal obesity) have worse bone microarchitecture. Serum P, ALP, CTX, TG, CRP, ESR, and WBC might have a negative association with TBS. Further studies are needed to clarify these findings.

Keyword

Bone Density; Waist circumference; Abdominal obesity; Phosphorus; Alkaline phosphatase

MeSH Terms

Absorptiometry, Photon
Alkaline Phosphatase
Blood Sedimentation
Body Mass Index
Bone Density
C-Reactive Protein
Female
Health Promotion
Humans
Logistic Models
Male
Obesity, Abdominal
Phosphorus
Retrospective Studies*
Seoul
Triglycerides
Waist Circumference
Alkaline Phosphatase
C-Reactive Protein
Phosphorus
Triglycerides