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A Correlation between Serum Level of Alkaline Phosphatase and Acne Severity in Children and Adolescents: A Retrospective Cross-Sectional Study

Jue MS, Park E, Kang HS, Kim JS

Background: Acne is a chronic inflammatory disease of the pilosebaceous unit and usually affects adolescents when the peak concentrations of growth hormone, insulin-like growth factor 1, and androgen are demonstrated....
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Case Report of Lethal Perinatal Hypophosphatasia with Seizure and Respiratory Failure Diagnosed by ALPL Gene Mutation

Lee SJ, Lee DW, Kim WD

Hypophosphatasia is a rare disease characterized by defective bone mineralization due to deficiency of tissue-nonspecific alkaline phosphatase. The patient was an 8-day-old male infant who presented with seizure since that...
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Chronic obstructive pulmonary disease severity in middle-aged and older men with steoporosis associates with decreased bone formation

Tsukamoto M, Mori T, Nakamura E, Okada Y, Fukuda H, Yamanaka Y, Sabanai K, Wang KY, Hanagiri T, Kuboi S, Yatera K, Sakai A

Objectives Chronic obstructive pulmonary disease (COPD) is a risk factor for osteoporosis. Nevertheless, much remains unclear regarding the bone metabolism dynamics associated with COPD. The present study focuses on the associations...
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Nationwide Cross-sectional Study of Association between Pterygium and Alkaline Phosphatase in a Population from Korea

Kim HJ, Rah SH, Kim SW, Kim SH

PURPOSE: We determined whether elevated serum alkaline phosphatase (ALP) was related to prevalence, location, type, length, and recurrence of pterygium in a population from the Republic of Korea. METHODS: A nationwide...
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Evaluation of Challenges in Diagnosis of Spontaneous Subacute Pyogenic Spondylodiscitis in Immunocompetent Patients: Experiences from a Tertiary Care Center

Pandita N, Paul S, Yadav G, Kalia RB, Kandwal P

STUDY DESIGN: Prospective clinical study. PURPOSE: We evaluated the challenges faced during diagnosis and management of patients with subacute pyogenic discitis and discussed various clues in clinical history, radiologic and hematologic...
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Serum alkaline phosphatase and γ-glutamyl transferase in acute pyelonephritis

Han C, Lee YK, Park HC, Cho A, Choi SR, Yoon JW, Koo JR, Kim HJ, Noh JW, Park MJ

BACKGROUND: Elevated serum alkaline phosphatase (AP) and γ-glutamyl transferase (γ-GT) are commonly observed in patients with acute pyelonephritis. The goal of this study was to examine the clinical significance of...
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The Prognostic Value of Albumin-to-Alkaline Phosphatase Ratio before Radical Radiotherapy in Patients with Non-metastatic Nasopharyngeal Carcinoma: A Propensity Score Matching Analysis

Kim JS, Keam B, Heo DS, Han DH, Rhee CS, Kim JH, Jung KC, Wu HG

PURPOSE: We first analyzed the prognostic power of albumin-to-alkaline phosphatase ratio (AAPR) before radical radiotherapy (RT) in non-metastatic nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: The records of 170 patients with...
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Stabilization of serum alkaline phosphatase in hemodialysis patients by implementation of local chronic kidney disease-mineral bone disorder management strategy: A quality improvement study

Jin K, Ban TH, Jung JY, Kim AJ, Kim Y, Lee SY, Yang DH, Choi BS, Oh KH, Kim J, Kwon YJ, Choi JW, Kim GH

BACKGROUND: The aim of this study is to narrow the gap between global guidelines and local practices, we recently established domestic recommendations by adapting the international guidelines for management of...
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Pilot Algorithm Designed to Help Early Detection of HMG-CoA Reductase Inhibitor-Induced Hepatotoxicity

Hong JY, Kim HS, Choi IY

OBJECTIVES: To enable early detection of adverse drug reactions (ADRs) in patients using HMG-CoA reductase inhibitors (statins), we developed an algorithm that automatically detects liver injury caused by statins from...
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Melanin extract from Gallus gallus domesticus promotes proliferation and differentiation of osteoblastic MG-63 cells via bone morphogenetic protein-2 signaling

Yoo HS, Chung KH, Lee KJ, Kim DH, An JH

BACKGROUND/OBJECTIVES: Gallus gallus domesticus (GD) is a natural mutant breed of chicken in Korea with an atypical characterization of melanin in its tissue. This study investigated the effects of melanin...
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Bone turnover rate and bone formation/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change

Nakatoh S

OBJECTIVES: This study aimed to investigate the correlation between bone mineral density (BMD) and the turnover rate [√(MoMf²+ MoMr²), multiple of median formation (MoMf) was calculated as bone-specific alkaline phosphatase...
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Effects of Scytosiphon lomentaria on osteoblastic proliferation and differentiation of MC3T3-E1 cells

Park MH, Kim S, Cheon J, Lee J, Kim BK, Lee SH, Kong C, Kim YY, Kim M

BACKGROUND/OBJECTIVES: Bone formation and bone resorption continuously occur in bone tissue to prevent the accumulation of old bone, this being called bone remodeling. Osteoblasts especially play a crucial role in...
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Clinical Factors Associated With Trabecular Bone Score in Koreans: A Retrospective Study

Chung EH, Lee SH, Kim JH, Park HJ, Min HY, Kim SH, Yun JM, Cho BL

BACKGROUND: The objective of our study was to examine the clinical factors associated with bone microarchitecture in Koreans. To the best of our knowledge, only a few studies have investigated...
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Assessment of the Role of Noni (Morinda citrifolia) Juice for Inducing Osteoblast Differentiation in Isolated Rat Bone Marrow Derived Mesenchymal Stem Cells

Hussain S, Tamizhselvi R, George L, Manickam V

BACKGROUND AND OBJECTIVES: Morinda citrifolia (Noni), an important traditional medicinal plant still used in patients with bone fractures or dislocation to promote connective tissue repair and to reduce inflammation. However,...
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Differentiation of Rat Dermal Mesenchymal Cells and Calcification in Three-Dimensional Cultures

Suyama T, Hatta M, Hata S, Ishikawa H, Yamazaki J

Three-dimensional (3D) cultures are known to promote cell differentiation. Previously, we investigated the differentiation of rat dermal fibroblasts to α-smooth muscle actin (α-SMA)-positive myofibroblasts through transforming growth factor (TGF)-β production...
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Bone Marrow Mesenchymal Stem Cell Transplantation in a Rabbit Corneal Alkali Burn Model (A Histological and Immune Histo-chemical Study)

Ahmed SK, Soliman AA, Omar SM, Mohammed W

BACKGROUND: Alkali-burned corneas can seldom heal properly to restore corneal transparency. Treatment of this severe disorder of the ocular surface remains a challenge. AIM OF THE WORK: was to investigate whether...
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Growth Properties and Pluripotency Marker Expression of Spontaneously Formed Three-dimensional Aggregates of Human Adipose-derived Stem Cells

Bogdanova-Jatniece A, Berzins U, Kozlovska

BACKGROUND AND OBJECTIVES: Recent findings suggest that therapeutic potential of mesenchymal stem cells (MSCs) could be increased through aggregation into three-dimensional (3D) bodies, and different culture methods have been employed...
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Clinical Characteristics of Primary Epstein Barr Virus Hepatitis with Elevation of Alkaline Phosphatase and gamma-Glutamyltransferase in Children

Yang SI, Geong JH, Kim JY

PURPOSE: The aim of the present study was to evaluate the clinical characteristics of the primary Epstein-Barr virus (EBV) hepatitis with elevation of both serum alkaline phosphatase (ALP) and gamma-glutamyltransferase...
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Serologic Markers of Excessive Callus formation in Traumatic Brain Injury Patient

Park HG, Kim YJ

  • KMID: 2297783
  • J Korean Soc Traumatol.
  • 2013 Sep;26(3):81-88.
PURPOSE: Among patients with multiple traumatic fractures, a tendency to form more callus exists in groups with multiple fractures combined with traumatic brain injury. This retrospective study evaluated the hematologic...
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Risk Factors of Post Endoscopic Retrograde Cholangiopancreatography Bacteremia

Kwak MS, Jang ES, Ryu JK, Kim YT, Yoon YB, Park JK

  • KMID: 2135075
  • Gut Liver.
  • 2013 Mar;7(2):228-233.
BACKGROUND/AIMS: Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study...
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