J Nutr Health.  2018 Jun;51(3):201-207. 10.4163/jnh.2018.51.3.201.

Anti-obesity and LDL-cholesterol lowering effects of silkworm hemolymph in C57BL/6N mice fed high fat diet

• Nam YR
• Ko YE
• Ly SY

• KMID: 2415216
• DOI: http://doi.org/10.4163/jnh.2018.51.3.201

Abstract

PURPOSE
Obesity, a worldwide epidemic, is associated with insulin resistance, hyperlipidemia, hypertension, cardiovascular disease, and certain cancers. Many strategies, including natural alternative anti-obesity agents, are used widely to prevent obesity. This study examined the effects of silkworm hemolymph on the weight control of C57BL/6N mice fed with a high-fat diet.
METHODS
The mice were divided into five groups: normal group (N), high-fat diet group (HFC), high-fat diet and silkworm hemolymph (at dose of 1 mL/kg BW (HFS-1), 5 mL/kg BW (HFS-5) and 10 mL/kg (HFS-10) for 12 weeks.
RESULTS
After 12 weeks treatment, the administration of silkworm hemolymph decreased the final body weight significantly along with a decrease in the weights of epididymal fat and total fat. The plasma LDL-cholesterol concentration was significantly lower in the HFS-1, HFS-5, and HFS-10 groups than in the HFC group. In addition, the leptin level of the HFS groups was significantly lower than those of the HFC group without a change in the plasma insulin concentration.
CONCLUSION
These findings suggest that the silkworm hemolymph may have the potential to prevent obesity.

Keyword

silkworm hemolymph; anti-obesity; LDL-cholesterol lowering effect

MeSH Terms

Animals
Anti-Obesity Agents
Body Weight
Bombyx*
Cardiovascular Diseases
Diet, High-Fat*
Hemolymph*
Hyperlipidemias
Hypertension
Insulin
Insulin Resistance
Leptin
Mice*
Obesity
Plasma
Weights and Measures
Anti-Obesity Agents
Insulin
Leptin

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