Clin Exp Reprod Med.  2018 Jun;45(2):94-99. 10.5653/cerm.2018.45.2.94.

A new biomarker for the early diagnosis of ovarian torsion: SCUBE-1

• Uyanikoglu H
• Hilali NG
• Yardimciel M
• Koyuncu I

• KMID: 2415105
• DOI: http://doi.org/10.5653/cerm.2018.45.2.94

Abstract

OBJECTIVE
Prompt diagnosis and management are essential for saving the adnexal organs from infarction in cases of ovarian torsion (OT). This study aimed to determine the diagnostic significance of signal peptide, complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels in cases of OT, an emergent ischemic condition, and the relationship of SCUBE-1 with oxidative stress parameters.
METHODS
This prospective study was conducted among 15 OT patients and 20 age- and gravidity-matched healthy women. SCUBE-1 serum concentrations were determined by using enzyme-linked immunosorbent assays. In addition, oxidative stress was evaluated by measuring the serum levels of advanced oxidation protein products (AOPP), ferric reducing ability of plasma (FRAP), and glutathione (GSH).
RESULTS
The SCUBE-1 titers were significantly higher in the patients with OT than in the controls (p=0.008). In addition, serum FRAP and GSH levels were significantly lower in the OT patients than in the controls (p < 0.001 for both). Serum AOPP levels were higher in the OT patients, but this trend was not statistically significant (p>0.05). Furthermore, there were no correlations between SCUBE-1 levels and age, gravidity, parity, cyst size, and AOPP, FRAP, or GSH levels (p>0.05).
CONCLUSION
We believe that SCUBE-1 may be a promising biomarker for the early diagnosis of OT.

Keyword

Detorsion; Ischemia; Ovarian torsion; Oxidative stress; SCUBE-1

MeSH Terms

Advanced Oxidation Protein Products
Complement System Proteins
Diagnosis
Early Diagnosis*
Enzyme-Linked Immunosorbent Assay
Female
Glutathione
Gravidity
Humans
Infarction
Ischemia
Oxidative Stress
Parity
Plasma
Prospective Studies
Protein Sorting Signals
Advanced Oxidation Protein Products
Complement System Proteins
Glutathione
Protein Sorting Signals