Gut Liver.  2017 Jan;11(1):93-101. 10.5009/gnl16031.

Diagnostic Accuracy of Hepatic Vein Arrival Time Performed with Contrast-Enhanced Ultrasonography for Cirrhosis: A Systematic Review and Meta-Analysis

• Kim G
• Shim KY
• Baik SK

• KMID: 2412160
• DOI: http://doi.org/10.5009/gnl16031

Abstract

BACKGROUND/AIMS
We identified reports in the literature regarding the diagnostic accuracy of hepatic vein arrival time (HVAT) measured by contrast-enhanced ultrasonography (CEUS) to assess hepatic fibrosis in cirrhosis.
METHODS
The Ovid MEDLINE, Embase, and Cochrane databases were searched for all studies published up to 23 July 2015 that evaluated liver status using CEUS and liver biopsy (LB). The QUADAS-II (quality assessment of diagnostic accuracy studies-II) was applied to assess the internal validity of the diagnostic studies. Selected studies were subjected to a meta-analysis with MetaDisc 1.4 and RevMan 5.3.
RESULTS
A total of 12 studies including 844 patients with chronic liver disease met our inclusion criteria. The overall summary sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of the HVAT measured by CEUS for the detection of cirrhosis compared to LB were 0.83 (95% confidence interval [CI], 0.77 to 0.89), 0.75 (95% CI, 0.69 to 0.79), 3.45 (95% CI, 1.60 to 7.43), and 0.28 (95% CI, 0.10 to 0.74), respectively. The summary diagnostic odds ratio (random effects model) was 15.23 (95% CI, 3.07 to 75.47), the summary receiver operator characteristics area under the curve was 0.74 (standard error [SE]=0.14), and the index Q was 0.69 (SE=0.11).
CONCLUSIONS
Based on a systematic review, the measurement of HVAT by CEUS exhibited an increased accuracy and correlation for the detection of cirrhosis.

Keyword

Contrast-enhanced ultrasonography; Hepatic fibrosis; Meta-analysis; Systematic review

MeSH Terms

Biopsy
Contrast Media
DNA-Binding Proteins
Drosophila Proteins
Hepatic Veins/*diagnostic imaging
Humans
Likelihood Functions
Liver Cirrhosis/*diagnostic imaging/pathology
ROC Curve
Sensitivity and Specificity
Transcription Factors
Ultrasonography
Ultrasonography, Doppler
Contrast Media
DNA-Binding Proteins
Drosophila Proteins
Transcription Factors